ArticleJournal of the Association for Research in Otolaryngology : JARO2011
Auditory cortex electrical stimulation suppresses tinnitus in rats.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Lack of Amino Acid Alterations Within the Cochlear Nucleus and the Auditory Cortex in Acoustic Trauma-Induced Tinnitus Rats Using In Vivo Microdialysis.Audiology research · 2024Article
- Transcriptional Profile Changes after Noise-Induced Tinnitus in Rats.Brain sciences · 2023Article
- Strain Comparison in Rats Differentiates Strain-Specific from More General Correlates of Noise-Induced Hearing Loss and Tinnitus.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Animal Models of Tinnitus Treatment: Cochlear and Brain Stimulation.Current topics in behavioral neurosciences · 2021Article
- Homeostatic activity regulation as a mechanism underlying the effect of brain stimulation.Bioelectronic medicine · 2019Review
- Blast-Induced Tinnitus and Elevated Central Auditory and Limbic Activity in Rats: A Manganese-Enhanced MRI and Behavioral Study.Scientific reports · 2017Article
- Chronic tinnitus and unipolar brush cell alterations in the cerebellum and dorsal cochlear nucleus.Hearing research · 2017Article
- Brain Metabolic Changes in Rats following Acoustic Trauma.Frontiers in neuroscience · 2017Article
- The effects of repetitive transcranial magnetic stimulation in an animal model of tinnitus.Scientific reports · 2016Article
- Meta-adaptation in the auditory midbrain under cortical influence.Nature communications · 2016Article
- GLAST Deficiency in Mice Exacerbates Gap Detection Deficits in a Model of Salicylate-Induced Tinnitus.Frontiers in behavioral neuroscience · 2016Article
- The olivocochlear reflex strength and cochlear sensitivity are independently modulated by auditory cortex microstimulation.Journal of the Association for Research in Otolaryngology : JARO · 2015Article
- Article
- Neural changes accompanying tinnitus following unilateral acoustic trauma in the guinea pig.The European journal of neuroscience · 2014Article
- Underlying mechanisms of tinnitus: review and clinical implications.Journal of the American Academy of Audiology · 2014Review
- Animal models of subjective tinnitus.Neural plasticity · 2014Review
- Effects of furosemide on cochlear neural activity, central hyperactivity and behavioural tinnitus after cochlear trauma in guinea pig.PloS one · 2014Article
- Changes in the response properties of inferior colliculus neurons relating to tinnitus.Frontiers in neurology · 2014Article
- Article
- The gap-startle paradigm for tinnitus screening in animal models: limitations and optimization.Hearing research · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Recent clinical studies have demonstrated that auditory cortex electrical stimulation (ACES) has yielded promising results in the suppression of patients' tinnitus. However, the large variability in the efficacy of ACES-induced suppression across individuals has hindered its development into a reliable therapy. Due to ethical reasons, many issues cannot be comprehensively addressed in patients. In order to search for effective stimulation targets and identify optimal stimulation strategies, we have developed the first rat model to test for the suppression of behavioral evidence of tone-induced tinnitus through ACES. Our behavioral results demonstrated that electrical stimulation of all channels (frequency bands) in the auditory cortex significantly suppressed behavioral evidence of tinnitus and enhanced hearing detection at the central level. Such suppression of tinnitus and enhancement of hearing detection were respectively demonstrated by a reversal of tone exposure compromised gap detection at 10-12, 14-16, and 26-28 kHz and compromised prepulse inhibition at 10-12 and 26-28 kHz. On the contrary, ACES did not induce behavioral changes in animals that did not manifest any behavioral evidence of tinnitus and compromised hearing detection following the same tone exposure. The results point out that tinnitus may be more related to compromised central auditory processing than hearing loss at the peripheral level. The ACES-induced suppression of behavioral evidence of tinnitus may involve restoration of abnormal central auditory processing.
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