ArticleFunctional & integrative genomics2011
Integrating miRNA and mRNA expression profiles in response to heat stress-induced injury in rat small intestine.
Article in Functional & integrative genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 59 citations in OpenAlex.
- Melatonin mitigates PGF-induced apoptosis during luteal regression in heat-exposed rats.Animal reproduction · 2025Article
- Exploring the Heat-Responsive miRNAs and their Target Gene Regulation in Ruditapes philippinarum Under Acute Heat Stress.Marine biotechnology (New York, N.Y.) · 2024Article
- Air Pollution: Role of Extracellular Vesicles-Derived Non-Coding RNAs in Environmental Stress Response.Cells · 2023Review
- Analysis of Genomic Alternative Splicing Patterns in Rat under Heat Stress Based on RNA-Seq Data.Genes · 2022Article
- Gene ssa-miR-301a-3p improves rainbow trout (PeerJ · 2022Article
- MicroRNA expression profiling during the suckling-to-weaning transition in pigs.Journal of animal science and technology · 2021Article
- The Mediation of miR-34a/miR-449c for Immune Cytokines in Acute Cold/Heat-Stressed Broiler Chicken.Animals : an open access journal from MDPI · 2020Article
- Article
- Analysis of miRNAs and their target genes associated with mucosal damage caused by transport stress in the mallard duck intestine.PloS one · 2020Article
- MicroRNAs: Crucial Regulators of Stress.MicroRNA (Shariqah, United Arab Emirates) · 2020Review
- Genomewide analysis of circular RNA in pituitaries of normal and heat-stressed sows.BMC genomics · 2019Article
- Selection of reference genes for miRNA quantitative PCR and its application in miR-34a/Sirtuin-1 mediated energy metabolism in Megalobrama amblycephala.Fish physiology and biochemistry · 2019Article
- Comparative Genomics Reveals the Genetic Mechanisms of Musk Secretion and Adaptive Immunity in Chinese Forest Musk Deer.Genome biology and evolution · 2019Article
- Analysis of miRNA-seq in the liver of common carp (Cyprinus carpio L.) in response to different environmental temperatures.Functional & integrative genomics · 2019Article
- Biliverdin administration regulates the microRNA-mRNA expressional network associated with neuroprotection in cerebral ischemia reperfusion injury in rats.International journal of molecular medicine · 2019Article
- Identifying Hub Genes for Heat Tolerance in Water Buffalo (Frontiers in genetics · 2019Article
- MiR-1246 is upregulated and regulates lung cell apoptosis during heat stress in feedlot cattle.Cell stress & chaperones · 2018Article
- Physiological response and microRNA expression profiles in head kidney of genetically improved farmed tilapia (GIFT, Oreochromis niloticus) exposed to acute cold stress.Scientific reports · 2018Article
- Identification and characterization of microRNAs in the intestinal tissues of sheep (Ovis aries).PloS one · 2018Article
- Hyperthermia exposure induces apoptosis and inhibits proliferation in HCT116 cells by upregulating miR-34a and causing transcriptional activation of p53.Experimental and therapeutic medicine · 2017Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The molecular mechanisms underlying the pathophysiology of heat stress in the small intestine remain undefined. Furthermore, little information is available concerning changes in microRNA (miRNA) expression following heat stress. The present study sought to evaluate miRNA and mRNA expression profiles in the rat small intestine in response to heat stress. Male Sprague-Dawley rats were subjected to 2 h of heat stress daily for ten consecutive days. Rats were sacrificed at specific time points immediately following heat treatment, and morphological changes in the small intestine were determined. The miRNA and mRNA expression profiles from sample of small intestine were evaluated by microarray analysis. Heat stress caused pronounced morphological damage in the rat small intestine, most severe within the jejunum after 3 days of heat treatment. A mRNA microarray analysis found 270 genes to be up-regulated and 122 genes down-regulated (P ≤ 0.01, ≥2.0-fold change) in the jejunum after heat treatment. A miRNA microarray analysis found 18 miRNAs to be up-regulated and 11 down-regulated in the jejunum after heat treatment (P ≤ 0.05). Subsequent bioinformatic analyses of the differentially expressed mRNAs and miRNAs were carried out to integrate miRNA and mRNA expression and revealed that alterations in mRNA following heat stress were negatively correlated with miRNA expression. These findings significantly advance our understanding of the regulatory mechanisms underlying the pathophysiology of heat stress-induced injury in the small intestine, specifically with regard to miRNAs.
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