ArticleParasitology research2011
Effects of curcumin (diferuloylmethane) on Eimeria tenella sporozoites in vitro.
Article in Parasitology research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 107 citations in OpenAlex.
- A novel serine/threonine protein phosphatase type 5 from second-generation merozoite of Eimeria tenella is associated with diclazuril-induced apoptosis.Parasitology research · 2013Trial
- Anticoccidial effect of halofuginone hydrobromide against Eimeria tenella with associated histology.Parasitology research · 2012Trial
- Anticoccidial Efficacy of Solid-Dispersion Formulations ContainingVeterinary sciences · 2026Article
- Insights into Non-Antibiotic Alternative and Emerging Control Strategies for Chicken Coccidiosis.Animals : an open access journal from MDPI · 2026Review
- Antioxidant properties of D-limonene and its nanoemulsion form enhance its anticoccidial efficiency in experimentally infected broilers with Eimeria tenella: an in vitro and in vivo study.Veterinary research communications · 2024Article
- Phytogenic feed additives as natural antibiotic alternatives in animal health and production: A review of the literature of the last decade.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Review
- Curcumin Supplementation Improves Growth Performance and Anticoccidial Index by Improving the Antioxidant Capacity, Inhibiting Inflammatory Responses, and Maintaining Intestinal Barrier Function inAnimals : an open access journal from MDPI · 2024Article
- Investigating the effects of essential oils and pure botanical compounds against Eimeria tenella in vitro.Poultry science · 2023Article
- Characterization and bioactivities ofSaudi journal of biological sciences · 2023Article
- A new insight in immunomodulatory impact of botanicals in treating avian coccidiosis.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Review
- Short Communication: effect of sodium butyrate, monensin, and butyric acid on the viability of Eimeria bovis sporozoites and their degree of damage to a bovine epithelial cell line.Journal of animal science · 2022Article
- Evaluation of the Anticoccidial Activity of Sheep Bile againstVeterinary sciences · 2022Article
- In Vitro Antioxidant, Antimicrobial, Anticoccidial, and Anti-Inflammatory Study of Essential Oils of Oregano, Thyme, and Sage from Epirus, Greece.Life (Basel, Switzerland) · 2022Article
- Two Novel Lipophilic Antioxidants Derivatized from Curcumin.Antioxidants (Basel, Switzerland) · 2022Article
- Medicinal Plants as an Alternative to Control Poultry Parasitic Diseases.Life (Basel, Switzerland) · 2022Review
- Phytochemical control of poultry coccidiosis: a review.Poultry science · 2022Review
- Effect of Pistacia lentiscus L. Vegetable Oil on Growth Performance and Coccidiosis in Broiler Chickens: In vitro and In vivo Assessment.Acta parasitologica · 2021Article
- In vitro infection of Madin-Darby bovine kidney (MDBK) cells with Eimeria acervulina sporozoites: quantitative analysis of parasite cellular invasion and replication using real-time polymerase chain reaction (PCR).Parasitology research · 2021Article
- In Vitro Assessment of Anticoccidials: Methods and Molecules.Animals : an open access journal from MDPI · 2021Review
- Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The negative effects of coccidiosis on poultry health and productivity and increasing problems related to drug resistance have stimulated the search for novel and alternative methods of control. The present study evaluates the anticoccidial activity of curcumin (diferuloylmethane), a natural polyphenolic compound abundant in the rhizome of the perennial herb turmeric (Curcuma longa) which is a spice and food colorant commonly used in curries and also used as medicinal herb. Its effects were evaluated on Eimeria tenella sporozoites, including morphological alterations, sporozoite viability and infectivity to Madin-Darby bovine kidney (MDBK) cells. Morphological alterations of the sporozoites were recorded as deformation due to swelling and cell membrane corrugations. Curcumin at concentrations of 25, 50, 100, 200 and 400 μM showed considerable effects on sporozoite morphology and viability in a dose-dependent manner after incubation over 3, 6, 18 and 24 h while lower curcumin concentrations (6.25 and 12.5 μM) were not effective. In comparison to the untreated control, sporozoite infectivity was reduced at curcumin concentrations of 100 and 200 μM by 41.6% and 72.8%, respectively. Negative effects of curcumin on MDBK cells were not seen at these concentrations; however, curcumin at concentrations of 1,800, 600 and 400 μM was toxic to MDBK cells and affected cell proliferation. In conclusion, curcumin exhibited a marked inhibitory effect in vitro on E. tenella sporozoites inducing morphological changes and reducing sporozoite viability and infectivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.