Evidence map›Paper›PMID 21057720›Full record

ArticleMethods of information in medicine2011

Effectiveness of lexico-syntactic pattern matching for ontology enrichment with clinical documents.

K Liu, W W Chapman, G Savova, C G Chute, N Sioutos, R S Crowley

Abstract readComparative StudyEvaluation Study
In one paragraph

Article in Methods of information in medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

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9citing papers in PubMed
–field-weighted citation impact
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3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Towards an Obesity-Cancer Knowledge Base: Biomedical Entity Identification and Relation Detection.Proceedings. IEEE International Conference on Bioinformatics and Biomedicine · 2016
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Similarity-Based Recommendation of New Concepts to a Terminology.AMIA ... Annual Symposium proceedings. AMIA Symposium
    Article
4 · The record

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5 · Who and what money

Authors and funding

6 authors.

K LiuDepartment of Biomedical Informatics, UPMC Cancer Pavilion, Suite 301, 5150 Centre Avenue, Pittsburgh, PA 15232, USA. kaihong@pitt.edu
W W Chapman
G Savova
C G Chute
N Sioutos
R S Crowley

Funding

STANFORD COMPOSITE(RMI)U54HG004028 · NHGRI · STANFORD UNIVERSITY · PI MUSEN, MARK A · 2005 to 2014
$36.2M
The ODIE Toolkit - Software for Information Extraction and Biomedical Ontology DeR01CA127979 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JACOBSON, REBECCA S · 2007 to 2010
$2.1M
NCI NIH HHS R01 CA127979NHGRI NIH HHS U54 HG004028
6 · The paper itself

Abstract

objectiveTo evaluate the effectiveness of a lexico-syntactic pattern (LSP) matching method for ontology enrichment using clinical documents.

methodsTwo domains were separately studied using the same methodology. We used radiology documents to enrich RadLex and pathology documents to enrich National Cancer Institute Thesaurus (NCIT). Several known LSPs were used for semantic knowledge extraction. We first retrieved all sentences that contained LSPs across two large clinical repositories, and examined the frequency of the LSPs. From this set, we randomly sampled LSP instances which were examined by human judges. We used a two-step method to determine the utility of these patterns for enrichment. In the first step, domain experts annotated medically meaningful terms (MMTs) from each sentence within the LSP. In the second step, RadLex and NCIT curators evaluated how many of these MMTs could be added to the resource. To quantify the utility of this LSP method, we defined two evaluation metrics: suggestion rate (SR) and acceptance rate (AR). We used these measures to estimate the yield of concepts and relationships, for each of the two domains.

resultsFor NCIT, the concept SR was 24%, and the relationship SR was 65%. The concept AR was 21%, and the relationship AR was 14%. For RadLex, the concept SR was 37%, and the relationship SR was 55%. The concept AR was 11%, and the relationship AR was 44%.

conclusionThe LSP matching method is an effective method for concept and concept relationship discovery in biomedical domains.

Indexed as

Artificial IntelligenceLearningMedical InformaticsSemanticsTerminology as TopicHumansNational Cancer Institute (U.S.)Natural Language ProcessingPathology, SurgicalRadiologyUnited States

Identifiers

PMID21057720
PMCPMC3125434

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.