ArticleCommunicative & integrative biology2010
Roles of the cytoskeleton in regulating EphA2 signals.
Article in Communicative & integrative biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 15 citations in OpenAlex.
- Mutations in Chromatin Modifier and Ephrin Signaling Genes in Vein of Galen Malformation.Neuron · 2019Article
- Molecular Mechanoneurobiology: An Emerging Angle to Explore Neural Synaptic Functions.BioMed research international · 2015Review
- CIB1 synergizes with EphrinA2 to regulate Kaposi's sarcoma-associated herpesvirus macropinocytic entry in human microvascular dermal endothelial cells.PLoS pathogens · 2014Article
- Eph receptor signaling and ephrins.Cold Spring Harbor perspectives in biology · 2013Review
- Polysialylated NCAM and ephrinA/EphA regulate synaptic development of GABAergic interneurons in prefrontal cortex.Cerebral cortex (New York, N.Y. : 1991) · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The lateral organizations of receptors in the cell membrane display a tremendous amount of complexity. In some cases, receptor functions can be attributed to specific spatial arrangements in the plasma membrane. We recently found that one member of the largest subfamily of receptor tyrosine kinases (RTKs), EphA2, is organized over micrometer length scales by the cell's own cytoskeleton, and that this can regulate receptor signaling functions. Spatial organization of the receptor was found to be highly associated with invasive character, and mechanical disruption of receptor organization altered key down-stream events in the EphA2 signaling pathway. In this Addendum article, we put forth possible models for why EphA2 and other receptors may employ mechanical and spatial inputs mediated by the cytoskeleton. We speculate that this class of input may be common, and contributes to the intricacies of cellular signaling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.