ArticleCancer biology & therapy2010
Genomic profiling of C/EBPβ2 transformed mammary epithelial cells: a role for nuclear interleukin-1β.
Article in Cancer biology & therapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- PRR13 expression as a prognostic biomarker in breast cancer: correlations with immune infiltration and clinical outcomes.Frontiers in molecular biosciences · 2025Article
- Metformin inhibits human non-small cell lung cancer by regulating AMPK-CEBPB-PDL1 signaling pathway.Cancer immunology, immunotherapy : CII · 2022Article
- C/EBPß Isoform Specific Gene Regulation: It's a Lot more Complicated than you Think!Journal of mammary gland biology and neoplasia · 2020Review
- C/EBPβ's role in determining Ras-induced senescence or transformation.Small GTPases · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
C/EBPβ is essential for mammary gland growth and development and has been associated with poor prognosis in breast cancer. Overexpression of C/EBPβ2 in MCF10A cells results in a variety of cancer phenotypes including EMT and ErbB independence. IL1β is dramatically upregulated in MCF10A-C/EBPβ2 cells but there is little, if any, processing to the mature 17 kD form. Although proIL1b has previously been considered to be biologically inactive, we demonstrate proIL1b is not only localized to the nucleus, but is also tightly associated with the chromatin. We show that proIL1β is bound at specific locations in the genome and is positioned in such a way to play a role in the cancer phenotypes observed in MCF10A-C/EBPβ2 cells. Moreover, nuclear IL1β is detected in some human breast tumor samples. This study demonstrates the presence of nuclear proIL1β in transformed mammary epithelial cells providing the first evidence that IL1β may be a dual function cytokine.
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Registered trials
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