ArticleApplied and environmental microbiology2011
Class 1 integrons, selected virulence genes, and antibiotic resistance in Escherichia coli isolates from the Minjiang River, Fujian Province, China.
Article in Applied and environmental microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 73 citations in OpenAlex.
- Relating Antimicrobial Resistance and Virulence in Surface-WaterMicroorganisms · 2023Article
- Comparative Analysis of Human and Animal E. coli: Serotyping, Antimicrobial Resistance, and Virulence Gene ProfilingAntibiotics (Basel, Switzerland) · 2022Article
- Antibiotics Resistance inInternational journal of microbiology · 2022Article
- High Prevalence of Drug Resistance and Class 1 Integrons inFrontiers in microbiology · 2021Article
- Article
- Occurrence of Bacterial Markers and Antibiotic Resistance Genes in Sub-Saharan Rivers Receiving Animal Farm Wastewaters.Scientific reports · 2019Article
- Antimicrobial Resistance, Virulence Factors, and Pathotypes ofPathogens (Basel, Switzerland) · 2019Article
- Antimicrobial Resistance in Class 1 Integron-Positive Shiga Toxin-ProducingMicroorganisms · 2018Article
- Antibiotic resistance genes in China: occurrence, risk, and correlation among different parameters.Environmental science and pollution research international · 2018Review
- Article
- Comparative prevalence of Escherichia coli carrying virulence genes and class 1 and 2 integrons in sub-tropical and cool temperate freshwater.Environmental science and pollution research international · 2017Article
- Detection of Integrons and Staphylococcal Cassette ChromosomeOsong public health and research perspectives · 2017Article
- Prevalence of Antibiotic-ResistantFrontiers in microbiology · 2017Article
- Genetic Investigation of Beta-Lactam Associated Antibiotic Resistance AmongThe open microbiology journal · 2017Article
- Exploring the Role of Coliform Bacteria in Class 1 Integron Carriage and Biofilm Formation During Drinking Water Treatment.Microbial ecology · 2016Article
- Prevalence of antibiotic resistance genes in antibiotic-resistant Escherichia coli isolates in surface water of Taihu Lake Basin, China.Environmental science and pollution research international · 2015Article
- Human Health Risk Assessment (HHRA) for environmental development and transfer of antibiotic resistance.Environmental health perspectives · 2013Review
- Impact of manure fertilization on the abundance of antibiotic-resistant bacteria and frequency of detection of antibiotic resistance genes in soil and on vegetables at harvest.Applied and environmental microbiology · 2013Article
- Human health implications of clinically relevant bacteria in wastewater habitats.Environmental science and pollution research international · 2013Review
- Molecular diversity of class 2 integrons in antibiotic-resistant gram-negative bacteria found in wastewater environments in China.Ecotoxicology (London, England) · 2013Article
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Widespread fecal pollution of surface waters in developing countries is a threat to public health and may represent a significant pathway for the global dissemination of antibiotic resistance. The Minjiang River drainage basin in Fujian Province is one of China's most intensive livestock and poultry production areas and is home to several million people. In the study reported here, Escherichia coli isolates (n = 2,788) were sampled (2007 and 2008) from seven surface water locations in the basin and evaluated by PCR for carriage of selected genes encoding virulence factors, primarily for swine disease. A subset of isolates (n = 500) were evaluated by PCR for the distribution and characteristics of class 1 integrons, and a subset of these (n = 200) were evaluated phenotypically for resistance to a range of antibiotics. A total of 666 (24%) E. coli isolates carried at least one of the virulence genes elt, fedA, astA, fasA, estA, stx(2e), paa, and sepA. Forty-one percent of the isolates harbored class 1 integrons, and these isolates had a significantly higher probability of resistance to tobramycin, cefoperazone, cefazolin, ciprofloxacin, norfloxacin, azitromycin, and rifampin than isolates with no class 1 integron detected. Frequencies of resistance to selected antibiotics were as high as or higher than those in fecal, wastewater, and clinical isolates in published surveys undertaken in China, North America, and Europe. Overall, E. coli in the Minjiang River drainage basin carry attributes with public health significance at very high frequency, and these data provide a powerful rationale for investment in source water protection strategies in this important agricultural and urban setting in China.
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