ArticleThe American journal of pathology2010
Bone marrow cell recruitment mediated by inducible nitric oxide synthase/stromal cell-derived factor-1alpha signaling repairs the acoustically damaged cochlear blood-labyrinth barrier.
Article in The American journal of pathology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 46 citations in OpenAlex.
- LDHA-mediated glycolysis in stria vascularis endothelial cells regulates macrophages function through CX3CL1-CX3CR1 pathway in noise-induced oxidative stress.Cell death & disease · 2025Article
- Blood-labyrinth barrier breakdown in Meniere's disease.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- NADPH Oxidase 3: Beyond the Inner Ear.Antioxidants (Basel, Switzerland) · 2024Review
- Temporal bone marrow of the rat and its connections to the inner ear.Frontiers in neurology · 2024Article
- Trends in perivascular macrophages research from 1997 to 2021: A bibliometric analysis.CNS neuroscience & therapeutics · 2023Article
- 6'-sialyllactose ameliorates the ototoxic effects of the aminoglycoside antibiotic neomycin in susceptible mice.Frontiers in immunology · 2023Article
- Targeting CXCL1 chemokine signaling for treating cisplatin ototoxicity.Frontiers in immunology · 2023Article
- VEGFA165 gene therapy ameliorates blood-labyrinth barrier breakdown and hearing loss.JCI insight · 2021Article
- The effect of endothelial progenitor cell transplantation on neointimal hyperplasia and reendothelialisation after balloon catheter injury in rat carotid arteries.Stem cell research & therapy · 2021Article
- Progenitor cell therapy for acquired pediatric nervous system injury: Traumatic brain injury and acquired sensorineural hearing loss.Stem cells translational medicine · 2021Review
- The Detrimental and Beneficial Functions of Macrophages After Cochlear Injury.Frontiers in cell and developmental biology · 2021Review
- The immune response after noise damage in the cochlea is characterized by a heterogeneous mix of adaptive and innate immune cells.Scientific reports · 2020Article
- Acoustic Trauma Causes Cochlear Pericyte-to-Myofibroblast-Like Cell Transformation and Vascular Degeneration, and Transplantation of New Pericytes Prevents Vascular Atrophy.The American journal of pathology · 2020Article
- Application of Mesenchymal Stem Cell Therapy and Inner Ear Regeneration for Hearing Loss: A Review.International journal of molecular sciences · 2020Review
- Macrophages in Noise-Exposed Cochlea: Changes, Regulation and the Potential Role.Aging and disease · 2020Review
- Genetic Hearing Loss Associated With Autoinflammation.Frontiers in neurology · 2020Review
- Macrophage migration inhibitory factor knockdown inhibit viability and induce apoptosis of PVM/Ms.Molecular medicine reports · 2017Article
- Matrix metalloproteinase-2 and -9 contribute to functional integrity and noise‑induced damage to the blood-labyrinth-barrier.Molecular medicine reports · 2017Article
- Aminoglycoside Increases Permeability of Osseous Spiral Laminae of Cochlea by Interrupting MMP-2 and MMP-9 Balance.Neurotoxicity research · 2017Article
- The Contribution of Immune Infiltrates to Ototoxicity and Cochlear Hair Cell Loss.Frontiers in cellular neuroscience · 2017Review
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Using a mouse model with noise-induced cochlear blood-labyrinth-barrier (CBLB) injury, we examined the effects of inducible nitric oxide synthase (iNOS) on the recruitment of bone marrow-derived cells (BMDCs) to the CBLB after acoustic injury. Lethally irradiated C57BL/6J and B6.129P2-Nos2(tm1Lau)/J mice were transplanted with GFP(+)-BMDCs from C57Bl/6-Tg (UBC GFP) mice. Four weeks after transplantation, we assessed the population of GFP(+)-BMDCs in the CBLB. Only small numbers of GFP(+)-BMDCs were found to infiltrate the area of the CBLB in the control recipient mice. However, robust GFP(+)-BMDC migration occurred in the area of the CBLB within the injured cochlea during the first week following acoustic trauma, and further BMDC accumulation was seen by 2 weeks posttrauma. After 4 weeks, the BMDCs were integrated into vessels. Local iNOS from perivascular resident macrophages was found to be important for BMDC infiltration, since mice deficient in iNOS (Inos(-/-)) and mice with iNOS that had been inhibited by 1400W displayed reduced BMDC infiltration. Stromal cell-derived factor-1α (SDF-1α) and its chemokine receptor 4 (CXCR4) were required for the iNOS-triggered recruitment. BMDC recruitment was significantly reduced by the inhibition of SDF-1α activity. Inhibition of the iNOS/SDF-1α signaling pathway reduced vascular repair as observed by reduced vascular density. Our study revealed an intrinsic signaling pathway of iNOS that mediates SDF-1α to promote GFP(+)-BMDC infiltration/targeting in cochlear vascular repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.