Evidence map›Paper›PMID 21056730›Full record

ReviewAdvances in immunology2010

How tolerogenic dendritic cells induce regulatory T cells.

Roberto A Maldonado, Ulrich H von Andrian

Abstract readReview
In one paragraph

Review in Advances in immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 281 papers.

0numbers the graph read from it
0cells of the map it votes in
281citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

281 citing papers in PubMed.

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  18. Thymic Dendritic Cells Revisited.Immunological reviews · 2025
    Review
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221 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Roberto A MaldonadoDepartment of Pathology, Harvard Medical School, Boston, Massachusetts, USA.
Ulrich H von Andrian

Funding

PREVENTION OF COLD INDUCED PLATELET STORAGE LESIONP01HL056949 · NHLBI · IMMUNE DISEASE INSTITUTE, INC. · PI WAGNER, DENISA D · 1996 to 2010
$26.2M
Visualizing Effects of Costimulation on Antiviral ImmunityP01AI078897 · NIAID · HARVARD MEDICAL SCHOOL · PI VON ANDRIAN, ULRICH H · 2008 to 2012
$12.1M
Virus discovery in cutaneous T cell lymphomaP30AR042689 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI KUPPER, THOMAS S. · 1994 to 2010
$6.8M
T Cell Activation in Lymph NodesR01AI069259 · NIAID · IMMUNE DISEASE INSTITUTE, INC. · PI VON ANDRIAN, ULRICH H · 2006 to 2015
$4.5M
Differentiation and Regulation of CTLR01AI072252 · NIAID · HARVARD MEDICAL SCHOOL · PI VON ANDRIAN, ULRICH H · 2007 to 2011
$2.1M
NHLBI NIH HHS HL56949NHLBI NIH HHS P01 HL056949NIAID NIH HHS AI069259NIAID NIH HHS AI072252NIAID NIH HHS AI078897NIAID NIH HHS P01 AI078897NIAID NIH HHS R01 AI069259NIAID NIH HHS R01 AI072252NIAMS NIH HHS AR42689NIAMS NIH HHS P30 AR042689
6 · The paper itself

Abstract

Since their discovery by Steinman and Cohn in 1973, dendritic cells (DCs) have become increasingly recognized for their crucial role as regulators of innate and adaptive immunity. DCs are exquisitely adept at acquiring, processing, and presenting antigens to T cells. They also adjust the context (and hence the outcome) of antigen presentation in response to a plethora of environmental inputs that signal the occurrence of pathogens or tissue damage. Such signals generally boost DC maturation, which promotes their migration from peripheral tissues into and within secondary lymphoid organs and their capacity to induce and regulate effector T cell responses. Conversely, more recent observations indicate that DCs are also crucial to ensure immunological peace. Indeed, DCs constantly present innocuous self- and nonself-antigens in a fashion that promotes tolerance, at least in part, through the control of regulatory T cells (Tregs). Tregs are specialized T cells that exert their immunosuppressive function through a variety of mechanisms affecting both DCs and effector cells. Here, we review recent advances in our understanding of the relationship between tolerogenic DCs and Tregs.

Indexed as

Immune ToleranceAnimalsAntigen PresentationCell CommunicationDendritic CellsHumansMiceT-Lymphocytes, Regulatory

Identifiers

PMID21056730
PMCPMC3050492

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.