ArticleInsect biochemistry and molecular biology2011
The kinin receptor is expressed in the Malpighian tubule stellate cells in the mosquito Aedes aegypti (L.): a new model needed to explain ion transport?
Article in Insect biochemistry and molecular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- Small molecules as arthropod kinin receptor antagonists, feeding modulators, or novel mosquitocidal agents.Pest management science · 2026Article
- Bromide is a surprisingly potent larvicide for Anopheles gambiae in the laboratory.Scientific reports · 2026Article
- Dynamics of release and activity of select neuropeptides post-bloodmeal in the female mosquito, Aedes aegypti.The Journal of experimental biology · 2025Article
- A fluorescently-tagged tick kinin neuropeptide triggers peristalsis and labels tick midgut muscles.Scientific reports · 2024Article
- Molecular characterization, localization, and physiological roles of ITP and ITP-L in the mosquito,Frontiers in insect science · 2024Article
- The V-type HProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Updates on ion and water transport by the Malpighian tubule.Current opinion in insect science · 2021Review
- Physiology, Development, and Disease Modeling in theGenetics · 2020Review
- Specialized stellate cells offer a privileged route for rapid water flux inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- The Cattle Fever Tick,Frontiers in physiology · 2019Article
- Leucokinin mimetic elicits aversive behavior in mosquito Aedes aegypti (L.) and inhibits the sugar taste neuron.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Article
- Tracing the evolutionary origins of insect renal function.Nature communications · 2015Article
- Article
- Chloride channels in stellate cells are essential for uniquely high secretion rates in neuropeptide-stimulated Drosophila diuresis.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Evidence for intercellular communication in mosquito renal tubules: a putative role of gap junctions in coordinating and regulating the rapid diuretic effects of neuropeptides.General and comparative endocrinology · 2014Review
- A biogenic amine and a neuropeptide act identically: tyramine signals through calcium in Drosophila tubule stellate cells.Proceedings. Biological sciences · 2013Article
- Phylogenetic investigation of Peptide hormone and growth factor receptors in five dipteran genomes.Frontiers in endocrinology · 2013Article
- Cloning and functional characterization of inward-rectifying potassium (Kir) channels from Malpighian tubules of the mosquito Aedes aegypti.Insect biochemistry and molecular biology · 2013Article
- Roles of PKC and phospho-adducin in transepithelial fluid secretion by Malpighian tubules of the yellow fever mosquito.Tissue barriers · 2013Article
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3 authors at 1 institution in 1 country.
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Abstract
It is known that insect kinins increase diuresis and fluid secretion in the Aedes aegypti Malpighian tubule, causing a rapid drop of the transepithelial resistance and increasing chloride conductance from the hemolymph towards the tubule lumen. The tubule is composed of both principal and stellate cells. The main route for increased chloride influx upon kinin treatment is proposed to be paracellular, with septate junctions acquiring increased chloride selectivity and conductance. Therefore, kinin treatment renders the Ae. aegypti tubule a "leaky epithelium", and under this model the kinin receptor is postulated to be expressed in principal cells. However, in another dipteran, the fruit fly Drosophila melanogaster, the main route for chloride transport is transcellular through stellate cells. In both the fruit fly and the mosquito Anopheles stephensi the kinin receptor has been immunolocalized in stellate cells, where it regulates transepithelial chloride permeability. Here we show that in Ae. aegypti, similarly, the stellate cells express the kinin receptor. This was confirmed through immunohistochemistry with two specific anti-kinin receptor antibodies and confocal analysis. The receptor is detected as a 75 kDa band in western blot. These results indicate that the currently accepted model for chloride transport must be re-evaluated in Ae. aegypti and suggest the kinin regulatory signals controlling intercellular junctions originate in the stellate cells.
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