ReviewTrends in neurosciences2010
The multiple pathways for itch and their interactions with pain.
Review in Trends in neurosciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06466421 (Clinical Study to Compare The Safety and Possible Efficacy of Fexofenadine Versus Gabapentin for Uremic Pruritus in Patients on Regular Hemodialysis), which is not on this map. Cited by 99 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Study to Compare The Safety and Possible Efficacy of Fexofenadine Versus Gabapentin for Uremic Pruritus in Patients on Regular Hemodialysis
Who cites it
99 citing papers in PubMed.
- Trial
- Nocebo Effects on Cowhage-evoked Itch: A Randomized Controlled Trial of Classical Conditioning and Observational Learning.Acta dermato-venereologica · 2021Trial
- The brain circuitry mediating antipruritic effects of acupuncture.Cerebral cortex (New York, N.Y. : 1991) · 2014Trial
- Piezo2 in Mechanosensory Biology: From Physiological Homeostasis to Disease-Promoting Mechanisms.Cell proliferation · 2026Review
- Gut microbiota and the kidney-gut-skin axis in chronic kidney disease-associated pruritus: mechanisms and therapeutic implications.Frontiers in cellular and infection microbiology · 2026Review
- Illness-related stigma mediates the association between disease severity and dermatology- specific quality of life in chronic inflammatory skin diseases: a structural equation modeling study.Frontiers in medicine · 2026Article
- Central neural circuits underlying itch sensation.Nature reviews. Neuroscience · 2025Review
- Cortical Control of Itch Sensation by Vasoactive Intestinal Polypeptide-Expressing Interneurons in the Anterior Cingulate Cortex.Neuroscience bulletin · 2025Article
- An intra-brainstem circuitry for pain-induced inhibition of itch.Neuroscience · 2025Article
- Processing of pain and itch information by modality-specific neurons within the anterior cingulate cortex in mice.Nature communications · 2025Article
- Kidney Disease: Improving Global Outcomes (KDIGO) Workshop on the Nurse's Role in Managing the Symptoms of People Receiving Dialysis.Kidney international reports · 2025Article
- Cell Type-Specific Modulation of Acute Itch Processing in the Anterior Cingulate Cortex.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- The nociceptive activity of peripheral sensory neurons is modulated by the neuronal membrane proteasome.Cell reports · 2024Article
- Mast cell-sensory neuron crosstalk in allergic diseases.The Journal of allergy and clinical immunology · 2024Review
- Article
- Neural pathways that compel us to scratch an itch.Journal of biosciences · 2024Review
- Peripheral signaling pathways contributing to non-histaminergic itch in humans.Journal of translational medicine · 2023Article
- Glutamatergic Neurons in the Zona Incerta Modulate Pain and Itch Behaviors in Mice.Molecular neurobiology · 2023Article
- Analyzing the Antinociceptive Effect of Interleukin-31 in Mice.International journal of molecular sciences · 2023Article
- Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Multiple neural pathways and molecular mechanisms responsible for producing the sensation of itch have recently been identified, including histamine-independent pathways. Physiological, molecular, behavioral and brain imaging studies are converging on a description of these pathways and their close association with pain processing. Some conflicting results have arisen and the precise relationship between itch and pain remains controversial. A better understanding of the generation of itch and of the intrinsic mechanisms that inhibit itch after scratching should facilitate the search for new methods to alleviate clinical pruritus (itch). In this review we describe the current understanding of the production and inhibition of itch. A model of itch processing within the CNS is proposed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.