ArticleAmerican journal of surgery2010
Extracellular pressure stimulates adhesion of sarcoma cells via activation of focal adhesion kinase and Akt.
Article in American journal of surgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- ZINC4085554 inhibits cancer cell adhesion by interfering with the interaction of Akt1 and FAK.Oncology letters · 2019Article
- Letter to the Editor: Pearls: The Mobile Segment in Sarcoma Resections.Clinical orthopaedics and related research · 2018Article
- Reply to the Letter to the Editor: Pearls: The Mobile Segment in Sarcoma Resections.Clinical orthopaedics and related research · 2018Article
- Article
- Targeting Focal Adhesion Kinase Suppresses the Malignant Phenotype in Rhabdomyosarcoma Cells.Translational oncology · 2016Article
- Moving beyond VEGF for anti-angiogenesis strategies in gynecologic cancer.Current pharmaceutical design · 2012Review
- Targeting focal adhesion kinase in neuroblastoma.Anti-cancer agents in medicinal chemistry · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe effect of extracellular pressure on adhesion and adhesiogenic focal adhesion kinase (FAK) and Akt signaling in sarcomas was investigated.
methodsHuman sarcoma cells (HT-1080 fibrosarcoma, KHOS-240S osteosarcoma, and A-673 rhabdomyosarcoma) were subjected to increased pressure followed by adhesion assay. Two cell lines were pretreated with the FAK inhibitor 1,2,4,5-benzenetetraamine tetrahydrochloride (Y15) or Akt IV inhibitor, followed by Western analysis for activated FAK and Akt. Parallel studies were conducted in cells from a resected human fibrous histiosarcoma.
resultsPressure increased adhesion in all 3 sarcoma lines and primary histosarcoma cells by 7% to 18% (n = 6; P < .01 each). Pressure activated FAK and Akt (n = 5; P < .01). Inhibiting FAK or Akt inhibited FAK or Akt phosphorylation and the stimulation of adhesion by increased pressure (n = 5 each; P < .01 each).
conclusionsPressure increases sarcoma cell adhesiveness via Akt and FAK. Perioperative manipulation or forces in lymphatic or circulatory systems may potentiate local recurrence or distant metastasis.
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Registered trials
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