Evidence map›Paper›PMID 21055734›Full record

ArticleCellular immunology2011

Preserved MHC-II antigen processing and presentation function in chronic HCV infection.

D H Canaday, C J Burant, L Jones, H Aung, L Woc-Colburn, D D Anthony

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Production of CD4⁺ and CD8⁺ T cell hybridomas.Methods in molecular biology (Clifton, N.J.) · 2013
    Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

D H CanadayGRECC, Louis Stokes Cleveland VA Hospital, United States. Dxc44@case.edu
C J Burant
L Jones
H Aung
L Woc-Colburn
D D Anthony
Case Western Reserve University · USLouis Stokes Cleveland VA Medical Center · USBaylor College of Medicine · US

Funding

WG3: HIV, Co-infections and Co-morbiditiesP30AI036219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI Sharon L. Hillier, JONATHAN KARN · 1994 to 2026
$50.0M
Mechanisms of increased susceptibility to TB in HIV-Infected individualsR01AI080313 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI CANADAY, DAVID H · 2010 to 2013
$2.0M
Role of immature DC in host defense against HCVR01DK068361 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI ANTHONY, DONALD D · 2006 to 2010
$1.3M
PULMONARY PATHOGEN DEFENSE MECHANISMST32HL007889 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI BOOM, HENRY · 1998 to 2007
$1.1M
Mechanisms of MHC-II antigen processing of HIV in macrophages and dendritic cellsR21AI073217 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI CANADAY, DAVID H · 2007 to 2008
$421k
NHLBI NIH HHS HL-07889NHLBI NIH HHS T32 HL007889NIAID NIH HHS AI-36219NIAID NIH HHS AI-73217NIAID NIH HHS N01 AI070022NIAID NIH HHS P30 AI036219NIAID NIH HHS R01 AI080313NIAID NIH HHS R21 AI073217NIDDK NIH HHS DK068361NIDDK NIH HHS R01 DK068361
6 · The paper itself

Abstract

Individuals with chronic HCV infection have impaired response to vaccine, though the etiology remains to be elucidated. Dendritic cells (DC) and monocytes (MN) provide antigen uptake, processing, presentation, and costimulatory functions necessary to achieve optimal immune responses. The integrity of antigen processing and presentation function within these antigen presenting cells (APC) in the setting of HCV infection has been unclear. We used a novel T cell hybridoma system that specifically measures MHC-II antigen processing and presentation function of human APC. Results demonstrate MHC-II antigen processing and presentation function is preserved in both myeloid DC (mDC) and MN in the peripheral blood of chronically HCV-infected individuals, and indicates that an alteration in this function does not likely underlie the defective HCV-infected host response to vaccination.

Indexed as

Antigen PresentationAgedDendritic CellsFemaleHepacivirusHepatitis C, ChronicHistocompatibility Antigens Class IIHumansHybridomasMaleMiddle AgedMonocytesT-LymphocytesHistocompatibility Antigens Class II

Identifiers

PMID21055734
PMCPMC3005840
OpenAlexW2064960753

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.