ArticleDevelopmental and comparative immunology2011
The zebrafish IgH locus contains multiple transcriptional regulatory regions.
Article in Developmental and comparative immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Mef2d regulates mutually exclusive expression of IgZ and IgM isotypes through epigenetic modulation in a zebrafish model.Fundamental research · 2026Article
- Mystifying Molecular Structure, Expression and Repertoire Diversity of IgM Heavy Chain Genes (Frontiers in immunology · 2022Article
- Goldfish, Carassius auratus, as an infection model for studying the pathogenesis of Edwardsiella piscicida.Veterinary research communications · 2017Article
- Functional anatomy of the immunoglobulin heavy chain 3΄ super-enhancer needs not only core enhancer elements but also their unique DNA context.Nucleic acids research · 2017Article
- Selective Manipulation of the Gut Microbiota Improves Immune Status in Vertebrates.Frontiers in immunology · 2015Review
- Expressed IgH μ and τ transcripts share diversity segment in ranched Thunnus orientalis.Developmental and comparative immunology · 2014Article
- A model 450 million years in the making: zebrafish and vertebrate immunity.Disease models & mechanisms · 2012Review
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Many fish have, in addition to IgM and IgD, a third isotype called IgZ or IgT. The ζ-chain locus is embedded among the Ig heavy chain V-, D- and J-elements in a manner reminiscent of the TcR δ/α locus. Isotype selection thus occurs during VDJ recombination, a process that is facilitated by intralocus transcription. Using in silico analyses and enhancer reporter vectors we identified 3 new regions within the zebrafish IgH locus through which transcription can be activated in catfish B-cell lines. Two of these, termed Eζi (Jζ to Cζ1 intronic) and Eζ3' regions flank the ζ-chain constant domain exons. A third region, Eδ3', resides downstream of the δ-chain exons. All regions contain predicted binding sites for transcription factors that contribute to B-cell specific transcription in fish and mammals. Each region also has proximal matrix attachment regions, which may further contribute to transcriptional activation and chromatin remodeling. We discuss possible roles for these regions during VDJ recombination.
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Registered trials
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