ArticleRespiratory research2010
SPLUNC1 regulation in airway epithelial cells: role of Toll-like receptor 2 signaling.
Article in Respiratory research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 27 citations in OpenAlex.
- Dendritic cells from aged subjects contribute to chronic airway inflammation by activating bronchial epithelial cells under steady state.Mucosal immunology · 2014Trial
- In vitro modelling of bacterial pneumonia: a comparative analysis of widely applied complex cell culture models.FEMS microbiology reviews · 2024Review
- CC16 drives VLA-2-dependent SPLUNC1 expression.Frontiers in immunology · 2023Article
- Article
- The Role of BPIFA1 in Upper Airway Microbial Infections and Correlated Diseases.BioMed research international · 2018Review
- An innate defense peptide BPIFA1/SPLUNC1 restricts influenza A virus infection.Mucosal immunology · 2018Article
- Cloning and sequence analysis of Wild Argali short palate, lung and nasal epithelium clone 1 cDNA.Asian-Australasian journal of animal sciences · 2017Article
- Article
- Bactericidal/Permeability-increasing protein fold-containing family member A1 in airway host protection and respiratory disease.American journal of respiratory cell and molecular biology · 2015Review
- Structural characterization of the pulmonary innate immune protein SPLUNC1 and identification of lipid ligands.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Electronic cigarette liquid increases inflammation and virus infection in primary human airway epithelial cells.PloS one · 2014Article
- Hands-on workshops as an effective means of learning advanced technologies including genomics, proteomics and bioinformatics.Genomics, proteomics & bioinformatics · 2013Article
- α1-Antitrypsin promotes SPLUNC1-mediated lung defense against Pseudomonas aeruginosa infection in mice.Respiratory research · 2013Article
- Short palate, lung, and nasal epithelial clone-1 is a tightly regulated airway sensor in innate and adaptive immunity.American journal of respiratory cell and molecular biology · 2013Article
- Cigarette smoke decreases airway epithelial FABP5 expression and promotes Pseudomonas aeruginosa infection.PloS one · 2013Article
- Human neutrophil elastase degrades SPLUNC1 and impairs airway epithelial defense against bacteria.PloS one · 2013Article
- Multifunctional role of human SPLUNC1 in Pseudomonas aeruginosa infection.Infection and immunity · 2013Article
- SPLUNC1 deficiency enhances airway eosinophilic inflammation in mice.American journal of respiratory cell and molecular biology · 2012Article
- Heat shock factor 1 protects against lung mycoplasma pneumoniae infection in mice.Journal of innate immunity · 2012Article
- Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundRespiratory infections including Mycoplasma pneumoniae (Mp) contribute to various chronic lung diseases. We have shown that mouse short palate, lung, and nasal epithelium clone 1 (SPLUNC1) protein was able to inhibit Mp growth. Further, airway epithelial cells increased SPLUNC1 expression upon Mp infection. However, the mechanisms underlying SPLUNC1 regulation remain unknown. In the current study, we investigated if SPLUNC1 production following Mp infection is regulated through Toll-like receptor 2 (TLR2) signaling.
methodsAirway epithelial cell cultures were utilized to reveal the contribution of TLR2 signaling including NF-κB to SPLUNC1 production upon bacterial infection and TLR2 agonist stimulation.
resultsMp and TLR2 agonist Pam3CSK4 increased SPLUNC1 expression in tracheal epithelial cells from wild type, but not TLR2(-/-) BALB/c mice. RNA interference (short-hairpin RNA) of TLR2 in normal human bronchial epithelial cells under air-liquid interface cultures significantly reduced SPLUNC1 levels in Mp-infected or Pam3CSK4-treated cells. Inhibition and activation of NF-κB pathway decreased and increased SPLUNC1 production in airway epithelial cells, respectively.
conclusionsOur data for the first time suggest that airway epithelial TLR2 signaling is pivotal in mycoplasma-induced SPLUNC1 production, thus improving our understanding of the aberrant SPLUNC1 expression in airways of patients suffering from chronic lung diseases with bacterial infections.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.