ArticleCerebrospinal fluid research2010
Diffusion tensor imaging correlates with cytopathology in a rat model of neonatal hydrocephalus.
Article in Cerebrospinal fluid research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Structural Alterations of the Corpus Callosum in Children With Infantile Hydrocephalus.Journal of child neurology · 2024Article
- Identification of key molecular biomarkers involved in reactive and neurodegenerative processes present in inherited congenital hydrocephalus.Fluids and barriers of the CNS · 2021Article
- Fractional anisotropy from diffusion tensor imaging correlates with acute astrocyte and myelin swelling in neonatal swine models of excitotoxic and hypoxic-ischemic brain injury.The Journal of comparative neurology · 2021Article
- Tract-Specific Relationships Between Cerebrospinal Fluid Biomarkers and Periventricular White Matter in Posthemorrhagic Hydrocephalus of Prematurity.Neurosurgery · 2021Article
- Myelination of Callosal Axons Is Hampered by Early and Late Forelimb Amputation in Rats.Cerebral cortex communications · 2021Article
- Neonatal hydrocephalus leads to white matter neuroinflammation and injury in the corpus callosum of Ccdc39 hydrocephalic mice.Journal of neurosurgery. Pediatrics · 2020Article
- Feasibility of fast brain diffusion MRI to quantify white matter injury in pediatric hydrocephalus.Journal of neurosurgery. Pediatrics · 2019Article
- MR diffusion changes in the perimeter of the lateral ventricles demonstrate periventricular injury in post-hemorrhagic hydrocephalus of prematurity.NeuroImage. Clinical · 2019Article
- Opportunities in posthemorrhagic hydrocephalus research: outcomes of the Hydrocephalus Association Posthemorrhagic Hydrocephalus Workshop.Fluids and barriers of the CNS · 2018Review
- Extended Combined Neonatal Treatment With Erythropoietin Plus Melatonin Prevents Posthemorrhagic Hydrocephalus of Prematurity in Rats.Frontiers in cellular neuroscience · 2018Article
- Diffusion tensor imaging study of pediatric patients with congenital hydrocephalus: 1-year postsurgical outcomes.Journal of neurosurgery. Pediatrics · 2016Article
- Diffusion tensor imaging with direct cytopathological validation: characterisation of decorin treatment in experimental juvenile communicating hydrocephalus.Fluids and barriers of the CNS · 2016Article
- Changes in Rat Brain Tissue Microstructure and Stiffness during the Development of Experimental Obstructive Hydrocephalus.PloS one · 2016Article
- Abnormal structural connectivity in the brain networks of children with hydrocephalus.NeuroImage. Clinical · 2015Article
- Differential vulnerability of white matter structures to experimental infantile hydrocephalus detected by diffusion tensor imaging.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2014Article
- Kaolin-induced ventriculomegaly at weaning produces long-term learning, memory, and motor deficits in rats.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2014Article
- DTI values in key white matter tracts from infancy through adolescence.AJNR. American journal of neuroradiology · 2013Article
- Longitudinal comparison of diffusion tensor imaging parameters and neuropsychological measures following endoscopic third ventriculostomy for hydrocephalus.Journal of neurosurgery. Pediatrics · 2012Article
- Wallerian degeneration in central nervous system: dynamic associations between diffusion indices and their underlying pathology.PloS one · 2012Article
- Diffusion tensor imaging of white matter injury in a rat model of infantile hydrocephalus.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2012Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundDiffusion tensor imaging (DTI) is a non-invasive MRI technique that has been used to quantify CNS abnormalities in various pathologic conditions. This study was designed to quantify the anisotropic diffusion properties in the brain of neonatal rats with hydrocephalus (HCP) and to investigate association between DTI measurements and cytopathology.
methodsDTI data were acquired between postnatal day 7 (P7) and P12 in 12 rats with HCP induced at P2 and in 15 age-matched controls. Animals were euthanized at P11 or P22/P23 and brains were processed with immunohistochemistry for glial fibrillary acidic protein (GFAP), ionized calcium-binding adaptor molecule (Iba-1), and luxol fast blue (LFB) to assess astrocytosis, microglial reactivity and degree of myelination, respectively.
resultsHydrocephalic rats were consistently found to have an abnormally low (at corrected p-level of <0.05) fractional anisotropy (FA) value and an abnormally high mean diffusivity (MD) value in the cerebral cortex (CX), the corpus callosum (CC), and the internal capsule (IC). Immunohistochemical analysis demonstrated trends of increasing astrocyte and microglial reactivity in HCP rats at P11 that reached statistical significance at P22/P23. A trend toward reduced myelination in the HCP rats was also found at P22/P23. Correlation analysis at P11 for the CC demonstrated statistically significant correlations (or trends) between the DTI measurement (the decreased FA and increased MD values) and the GFAP or Iba-1 rankings. The immunohistochemical rankings in the IC at P22/P23 were also significantly correlated or demonstrated a trend with both FA and MD values.
conclusionsThis study demonstrates the feasibility of employing DTI on the brain in experimental hydrocephalus in neonatal rats and reveals impairments in multiple regions of interest in both grey and white matter. A strong correlation was found between the immunohistochemical results and the changes in anisotropic diffusion properties.
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Registered trials
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