ArticleBMC genetics2010
Polymorphisms in bovine immune genes and their associations with somatic cell count and milk production in dairy cattle.
Article in BMC genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 90 citations in OpenAlex.
- Polymorphism in the TLR Adaptors of the Toll Signalling Pathway for Use in Livestock Breeding for Health Traits.International journal of molecular sciences · 2026Review
- Genome-wide study for signatures of selection identifies genomic regions and candidate genes associated with milk traits in sheep.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- Genomic characteristics of performance traits and adaptation to heat stress in desert Barki sheep.Archives animal breeding · 2025Review
- Toll like receptor 4 (TLR4) gene polymorphism and its association with somatic cell score and milk production traits in Indian dromedary camels.Animal biotechnology · 2024Article
- Association of Variants in Innate Immune GenesGenes · 2023Article
- Candidate genes for mastitis resistance in dairy cattle: a data integration approach.Journal of animal science and biotechnology · 2023Article
- Genetic polymorphisms in immune- and inflammation-associated genes and their association with bovine mastitis resistance/susceptibility.Frontiers in immunology · 2023Review
- The variation in promoter sequences of the Akt3 gene between cow and buffalo revealed different responses against mastitis.Journal, genetic engineering & biotechnology · 2021Article
- A missense mutation in the coding region of the toll-like receptor 4 gene affects milk traits in Barki sheep.Animal bioscience · 2021Article
- Bovine mastitis prevention and control in the post-antibiotic era.Tropical animal health and production · 2021Review
- SNP Diversity inGenes · 2020Article
- Polymorphisms inFrontiers in veterinary science · 2020Article
- Article
- Genomic Patterns of Homozygosity in Chinese Local Cattle.Scientific reports · 2019Article
- Potential ofArchives animal breeding · 2019Article
- Association of leptin, toll-like receptor 4, and chemokine receptor of interleukin 8 C-X-C motif single nucleotide polymorphisms with fertility traits in Czech Fleckvieh cattle.Asian-Australasian journal of animal sciences · 2018Article
- Article
- Molecular characterization and combined genotype association study of bovine cluster of differentiation 14 gene with clinical mastitis in crossbred dairy cattle.Veterinary world · 2016Article
- RNA-Seq reveals 10 novel promising candidate genes affecting milk protein concentration in the Chinese Holstein population.Scientific reports · 2016Article
- Case-control approach application for finding a relationship between candidate genes and clinical mastitis in Holstein dairy cattle.Journal of applied genetics · 2016Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMastitis, an inflammation of the mammary gland, is a major source of economic loss on dairy farms. The aim of this study was to quantify the associations between two previously identified polymorphisms in the bovine toll-like receptor 2 (TLR2) and chemokine receptor 1 (CXCR1) genes and mammary health indictor traits in (a) 246 lactating dairy cow contemporaries representing five breeds from one research farm and (b) 848 Holstein-Friesian bulls that represent a large proportion of the Irish dairy germplasm. To expand the study, a further 14 polymorphisms in immune genes were included for association studies in the bull population.
resultsTLR4-2021 associated (P < 0.05) with both milk protein and fat percentage in late lactation (P < 0.01) within the cow cohort. No association was observed between this polymorphism and either yield or composition of milk within the bull population. CXCR1-777 significantly associated (P < 0.05) with fat yield in the bull population and tended to associate (P < 0.1) with somatic cell score (SCS) in the cows genotyped. CD14-1908 A allele was found to associate with increased (P < 0.05) milk fat and protein yield and also tended to associate with increased (P < 0.1) milk yield. A SERPINA1 haplotype with superior genetic merit for milk protein yield and milk fat percentage (P < 0.05) was also identified.
conclusionOf the sixteen polymorphisms in seven immune genes genotyped, just CXCR1-777 tended to associate with SCS, albeit only in the on-farm study. The lack of an association between the polymorphisms with SCS in the Holstein-Friesian data set would question the potential importance of these variants in selection for improved mastitis resistance in the Holstein-Friesian cow.
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