ArticleJournal of veterinary internal medicine
Estimated frequency of the canine hyperuricosuria mutation in different dog breeds.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- PCR-based detection of hereditary mutations inJournal of veterinary science · 2025Article
- Molecular epidemiological study of germline APC variant associated with hereditary gastrointestinal polyposis in dogs: current frequency in Jack Russell Terriers in Japan and breed distribution.BMC veterinary research · 2022Article
- Web resource on available DNA variant tests for hereditary diseases and genetic predispositions in dogs and cats: An Update.Human genetics · 2021Article
- Urolithiasis in dogs: Evaluation of trends in urolith composition and risk factors (2006-2018).Journal of veterinary internal medicine · 2021Article
- Urolithiasis in cats: Evaluation of trends in urolith composition and risk factors (2005-2018).Journal of veterinary internal medicine · 2021Article
- Frequency and distribution of 152 genetic disease variants in over 100,000 mixed breed and purebred dogs.PLoS genetics · 2018Article
- Frequency of five disease-causing genetic mutations in a large mixed-breed dog population (2011-2012).PloS one · 2017Article
- Analysis of canine urolith submissions to the Canadian Veterinary Urolith Centre, 1998-2014.The Canadian veterinary journal = La revue veterinaire canadienne · 2017Article
- Evaluation of 21 426 feline bladder urolith submissions to the Canadian Veterinary Urolith Centre (1998-2014).The Canadian veterinary journal = La revue veterinaire canadienne · 2016Article
- Article
- Primary portal vein hypoplasia and SLC2A9 mutation associated with urate urolithiasis in a Spanish water dog.The Canadian veterinary journal = La revue veterinaire canadienne · 2015Article
- The prevalence of nine genetic disorders in a dog population from Belgium, the Netherlands and Germany.PloS one · 2013Article
- Stones in cats and dogs: What can be learnt from them?Arab journal of urology · 2012Review
- DNA testing and domestic dogs.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundHyperuricosuria is a condition that predisposes dogs to urate urolithiasis. A mutation that causes canine hyperuricosuria was previously identified in 3 unrelated dog breeds. The occurrence of the mutation in additional breeds was not determined. HYPOTHESIS/
objectivesIdentify additional breeds that have the hyperuricosuria mutation and estimate the mutant allele frequency in those breeds. ANIMALS: Three thousand five hundred and thirty dogs from 127 different breeds were screened for the hyperuricosuria mutation.
methodsDNA samples were genotyped by pyrosequencing and allele-specific polymerase chain reaction methods.
resultsMutant allele frequencies that range from 0.001 to 0.15 were identified in the American Staffordshire Terrier, Australian Shepherd, German Shepherd Dog, Giant Schnauzer, Parson (Jack) Russell Terrier, Labrador Retriever, Large Munsterlander, Pomeranian, South African Boerboel, and Weimaraner breeds. CONCLUSIONS AND CLINICAL IMPORTANCE: The hyperuricosuria mutation has been identified in several unrelated dog breeds. The mutant allele frequencies vary among breeds and can be used to determine an appropriate breeding plan for each breed. A DNA test is available and may be used by breeders to decrease the mutant allele frequency in breeds that carry the mutation. In addition, veterinarians may use the test as a diagnostic tool to identify the cause of urate urolithiasis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.