ArticleJournal of neurotrauma2011
A longitudinal proton magnetic resonance spectroscopy study of mild traumatic brain injury.
Article in Journal of neurotrauma, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
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Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 156 citations in OpenAlex.
- Using neuroimaging to identify sex differences in adults with sports-related concussion: a systematic review.Brain imaging and behavior · 2025Pooled it
- Magnetic Resonance Spectroscopy of Traumatic Brain Injury and Subconcussive Hits: A Systematic Review and Meta-Analysis.Journal of neurotrauma · 2022Pooled it
- Multi-modal proton and sodium MRI for outcome prediction in mild traumatic brain injury.Journal of neurology · 2025Article
- Assessment of White Matter Changes Using Quantitative T1ρ Mapping in an Open-Field Low-Intensity Blast Mouse Model of Mild Traumatic Brain Injury (mTBI).International journal of molecular sciences · 2025Article
- Associations Between Brain Metabolites Measured With MR Spectroscopy and Head Impacts in High School American Football Athletes.Journal of magnetic resonance imaging : JMRI · 2025Article
- Functional outcome after late cranioplasty after decompressive craniectomy: a single-center retrospective study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Article
- Brain metabolites measured with magnetic resonance spectroscopy in pediatric concussion and orthopedic injury: An Advancing Concussion Assessment in Pediatrics (A-CAP) study.Human brain mapping · 2023Article
- Brain Spectroscopy Analysis in Retired Soccer Players With Chronic Exposure to Mild Traumatic Brain Injuries.Neurotrauma reports · 2023Article
- Neurometabolite alterations in traumatic brain injury and associations with chronic pain.Frontiers in neuroscience · 2023Article
- Acute effects of single and repeated mild traumatic brain injury on levels of neurometabolites, lipids, and mitochondrial function in male rats.Frontiers in molecular neuroscience · 2023Article
- The clinical utility of proton magnetic resonance spectroscopy in traumatic brain injury: recommendations from the ENIGMA MRS working group.Brain imaging and behavior · 2021Article
- Alternative substrate metabolism depends on cerebral metabolic state following traumatic brain injury.Experimental neurology · 2020Article
- Electrophysiological Markers of Visuospatial Attention Recovery after Mild Traumatic Brain Injury.Brain sciences · 2019Article
- Quantitative multivoxel proton MR spectroscopy for the identification of white matter abnormalities in mild traumatic brain injury: Comparison between regional and global analysis.Journal of magnetic resonance imaging : JMRI · 2019Article
- Imaging of glutamate in acute traumatic brain injury using chemical exchange saturation transfer.Quantitative imaging in medicine and surgery · 2019Article
- Neurotransmitter changes after traumatic brain injury: an update for new treatment strategies.Molecular psychiatry · 2019Review
- Electrophysiological Responses to Emotional Facial Expressions Following a Mild Traumatic Brain Injury.Brain sciences · 2019Article
- Elevated cerebrospinal fluid concentrations of N-acetylaspartate correlate with poor outcome in a pilot study of severe brain trauma.Brain injury · 2019Article
- MRS and DTI evidence of progressive posterior cingulate cortex and corpus callosum injury in the hyper-acute phase after Traumatic Brain Injury.Brain injury · 2019Article
- Neuro-Metabolite Changes in a Single Season of University Ice Hockey Using Magnetic Resonance Spectroscopy.Frontiers in neurology · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Despite the prevalence and impact of mild traumatic brain injury (mTBI), common clinical assessment methods for mTBI have insufficient sensitivity and specificity. Moreover, few researchers have attempted to document underlying changes in physiology as a function of recovery from mTBI. Proton magnetic resonance spectroscopy (¹H-MRS) was used to assess neurometabolite concentrations in a supraventricular tissue slab in 30 individuals with semi-acute mTBI, and 30 sex-, age-, and education-matched controls. No significant group differences were evident on traditional measures of attention, memory, working memory, processing speed, and executive skills, though the mTBI group reported significantly more somatic, cognitive, and emotional symptoms. At a mean of 13 days post-injury, white matter concentrations of creatine (Cre) and phosphocreatine (PCre) and the combined glutamate-glutamine signal (Glx) were elevated in the mTBI group, while gray matter concentrations of Glx were reduced. Partial normalization of these three neurometabolites and N-acetyl aspartate occurred in the early days post-injury, during the semi-acute period of recovery. In addition, 17 mTBI patients (57%) returned for a follow-up evaluation (mean = 120 days post-injury). A significant group × time interaction indicated recovery in the mTBI group for gray matter Glx, and trends toward recovery in white matter Cre and Glx. An estimate of premorbid intelligence predicted the magnitude of neurometabolite normalization over the follow-up interval for the mTBI group, indicating that biological factors underlying intelligence may also be associated with more rapid recovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.