ArticleJournal of biomedical optics
Enhancing precision in time-domain fluorescence lifetime imaging.
Article in Journal of biomedical optics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed.
- A computational super-resolution framework for multidimensional fluorescence imaging.Science advances · 2026Article
- Multicolor lifetime imaging and its application to HIV-1 uptake.Nature communications · 2023Article
- Article
- Article
- Total variation versus wavelet-based methods for image denoising in fluorescence lifetime imaging microscopy.Journal of biophotonics · 2012Article
- Time-domain fluorescence lifetime imaging techniques suitable for solid-state imaging sensor arrays.Sensors (Basel, Switzerland) · 2012Article
- FRAP, FLIM, and FRET: Detection and analysis of cellular dynamics on a molecular scale using fluorescence microscopy.Molecular reproduction and developmentReview
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
In biological applications of fluorescence lifetime imaging, low signals from samples can be a challenge, causing poor lifetime precision. We demonstrate how optimal signal gating (a method applied to the temporal dimension of a lifetime image) and novel total variation denoising models (a method applied to the spatial dimension of a lifetime image) can be used in time-domain fluorescence lifetime imaging microscopy (FLIM) to improve lifetime precision. In time-gated FLIM, notable fourfold precision improvements were observed in a low-light example. This approach can be employed to improve FLIM data while minimizing sample light exposure and increasing imaging speed.
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Registered trials
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