ArticleDigestive diseases and sciences2011
Intercellular space volume is mainly increased in the basal layer of esophageal squamous epithelium in patients with GERD.
Article in Digestive diseases and sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 22 citations in OpenAlex.
- Proton Pump Inhibitor Therapy for Eosinophilic Esophagitis: History, Mechanisms, Efficacy, and Future Directions.Journal of asthma and allergy · 2022Review
- Tojapride Reverses Esophageal Epithelial Inflammatory Responses on Reflux Esophagitis Model Rats.Chinese journal of integrative medicine · 2021Article
- Epithelial Claudin Proteins and Their Role in Gastrointestinal Diseases.Journal of pediatric gastroenterology and nutrition · 2019Article
- A weakly acidic solution containing deoxycholic acid induces esophageal epithelial apoptosis and impairs integrity in an in vivo perfusion rabbit model.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- Ultrastructural features of eosinophilic oesophagitis: impact of treatment on desmosomes.Journal of clinical pathology · 2015Article
- Gastroesophageal reflux symptoms not responding to proton pump inhibitor: GERD, NERD, NARD, esophageal hypersensitivity or dyspepsia?Canadian journal of gastroenterology & hepatology · 2014Article
- Role of tight junction proteins in gastroesophageal reflux disease.BMC gastroenterology · 2012Article
- [Usefulness of Mean Nocturnal Basal Impedance in Patients with Suspected Non-Erosive Gastroesophageal Reflux Disease Refractory to Proton Pump Inhibitors].Acta gastroenterologica LatinoamericanaArticle
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7 authors at 2 institutions in 1 country.
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Abstract
BACKGROUND/
aimsAt present, the dilation of esophageal intercellular spaces (ICS) is considered an early morphologic marker of acid damage in patients with GERD. Nevertheless, previous electron microscopic (EM) studies had focused only on the suprabasal layer of squamous epithelium or did not nearly specify which layer of squamous epithelium was studied. Therefore, we aimed to assess the volumetric amount of the ICS in all layers of SE in patients with GERD.
methodsIn this study, 48 patients were prospectively included (NERD = 18, ERD = 17; Barrett's esophagus = 5, controls = 8). All patients with ERD and NERD had typical reflux symptoms, as assessed by a valid GERD questionnaire. ICS volume was assessed by electron microscopy in the superficial, prickle cell, and basal layers of esophageal squamous epithelium using the method of Weibel.
resultsERD was associated with increased ICS volume in the basal layer (LA-A, p = 0.038; LA-B, p = 0.005) and prickle cell layer (LA-A, p = 0.006; LA-B, p = 0.007) as compared to controls. Comparisons between NERD and ERD patients revealed more dilated ICS in the basal layer (LA-B, p = 0.007), prickle cell layer (LA-A, p = 0.008; LA-B, p = 0.001) and superficial layer (LA-B, p = 0.018) in patients with ERD.
conclusionsNot only the diameter but also the volume of the ICS is increased in patients with GERD. Furthermore, the dilation of ICS is present in all three layers of the SE, being more pronounced in the basal layer. These findings support the concept that the impairment of the esophagus begins in the deeper parts of the esophageal epithelium.
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