ArticleNeurochemical research2011
Insulin and β-adrenergic receptors inhibit retinal endothelial cell apoptosis through independent pathways.
Article in Neurochemical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- miRNA15a regulates insulin signal transduction in the retinal vasculature.Cellular signalling · 2018Article
- miR-146a suppresses STAT3/VEGF pathways and reduces apoptosis through IL-6 signaling in primary human retinal microvascular endothelial cells in high glucose conditions.Vision research · 2017Article
- Astragaloside IV protects rat retinal capillary endothelial cells against high glucose-induced oxidative injury.Drug design, development and therapy · 2017Article
- Notoginsenoside R1 attenuates high glucose-induced endothelial damage in rat retinal capillary endothelial cells by modulating the intracellular redox state.Drug design, development and therapy · 2017Article
- Protective Effects of Panax notoginseng Saponins against High Glucose-Induced Oxidative Injury in Rat Retinal Capillary Endothelial Cells.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- miR-15b/16 protects primary human retinal microvascular endothelial cells against hyperglycemia-induced increases in tumor necrosis factor alpha and suppressor of cytokine signaling 3.Journal of neuroinflammation · 2015Article
- Regulation of β-adrenergic receptor trafficking and lung microvascular endothelial cell permeability by Rab5 GTPase.International journal of biological sciences · 2015Article
- Attenuation of choroidal neovascularization by β(2)-adrenoreceptor antagonism.JAMA ophthalmology · 2013Article
- Reduced insulin receptor signaling in retinal Müller cells cultured in high glucose.Molecular vision · 2013Article
- Retinal endothelial cell apoptosis.Apoptosis : an international journal on programmed cell death · 2012Review
- TNFα and SOCS3 regulate IRS-1 to increase retinal endothelial cell apoptosis.Cellular signalling · 2012Article
- Silencing of insulin receptor substrate-1 increases cell death in retinal Müller cells.Molecular vision · 2012Article
- Increased tumor necrosis factor-α, cleaved caspase 3 levels and insulin receptor substrate-1 phosphorylation in the β₁-adrenergic receptor knockout mouse.Molecular vision · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Diabetic retinopathy results from altered insulin receptor signaling. Based on previous studies demonstrating an interaction between β-adrenergic receptors and insulin signaling in hyperglycemic conditions, we hypothesized that β-adrenergic receptor stimulation and insulin stimulation would act synergistically to inhibit one of the hallmarks of diabetic retinopathy, namely retinal endothelial cell apoptosis. To test this hypothesis, human retinal endothelial cells were grown in high glucose (25 mM) medium and treated with a β-1-adrenergic receptor agonist (xamoterol, 10 μM) alone, insulin alone (10 nM) or xamoterol + insulin. We then assessed changes in the levels of insulin receptor, insulin-like growth factor (IGF-1) receptor, and Akt phosphorylation, as well as cleaved caspase 3. Xamoterol alone significantly decreased insulin receptor, IGF-1 receptor and Akt phosphorylation, whereas insulin alone increased insulin receptor, IGF-1 receptor, and Akt phosphorylation. Xamoterol significantly decreased apoptosis of retinal endothelial cells. This data suggests that both β-adrenergic receptors and insulin can inhibit retinal endothelial cell apoptosis in hyperglycemic conditions, but inhibition occurs through independent pathways. These findings have implications for treatments of diabetic retinopathy.
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Registered trials
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