ReviewStem cell reviews and reports2011
The stem cell niche should be a key issue for cell therapy in regenerative medicine.
Review in Stem cell reviews and reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 61 citations in OpenAlex.
- Still finding ways to augment the existing management of acute and chronic kidney diseases with targeted gene and cell therapies: Opportunities and hurdles.Frontiers in medicine · 2023Review
- Bioengineering solutions for ureteric disorders: clinical need, challenges and opportunities.BJU international · 2022Review
- Cartilage Repair by Mesenchymal Stem Cell-Derived Exosomes: Preclinical and Clinical Trial Update and Perspectives.Advances in experimental medicine and biology · 2021Article
- Current Progress in the Endogenous Repair of Intervertebral Disk Degeneration Based on Progenitor Cells.Frontiers in bioengineering and biotechnology · 2020Review
- Mesenchymal Stromal Cell Immunology for Efficient and Safe Treatment of Osteoarthritis.Frontiers in cell and developmental biology · 2020Review
- Exosomes derived from mature chondrocytes facilitate subcutaneous stable ectopic chondrogenesis of cartilage progenitor cells.Stem cell research & therapy · 2018Article
- Engineered stem cell niche matrices for rotator cuff tendon regenerative engineering.PloS one · 2017Article
- Application of Tendon Stem/Progenitor Cells and Platelet-Rich Plasma to Treat Tendon Injuries.Operative techniques in orthopaedics · 2016Article
- Modelling the regenerative niche: a major challenge in biomaterials research.Regenerative biomaterials · 2015Review
- Spatiotemporal Analyses of Osteogenesis and Angiogenesis via Intravital Imaging in Cranial Bone Defect Repair.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Article
- Evaluation of posterolateral lumbar fusion in sheep using mineral scaffolds seeded with cultured bone marrow cells.International journal of molecular sciences · 2014Article
- New perspectives for articular cartilage repair treatment through tissue engineering: A contemporary review.World journal of orthopedics · 2014Review
- Mesenchymal stem cells secretome: a new paradigm for central nervous system regeneration?Cellular and molecular life sciences : CMLS · 2013Review
- Mesenchymal stem cell mechanobiology and emerging experimental platforms.Journal of the Royal Society, Interface · 2013Article
- Focus on cardiac pericytes.Pflugers Archiv : European journal of physiology · 2013Review
- Tendon regeneration in human and equine athletes: Ubi Sumus-Quo Vadimus (where are we and where are we going to)?Sports medicine (Auckland, N.Z.) · 2012Review
- A method to integrate patterned electrospun fibers with microfluidic systems to generate complex microenvironments for cell culture applications.Biomicrofluidics · 2012Article
- Stem cells: novel players in the treatment of erectile dysfunction.Asian journal of andrology · 2012Review
- Potential stemness of frozen-thawed testicular biopsies without sperm in infertile men included into the in vitro fertilization programme.Journal of biomedicine & biotechnology · 2012Article
- Enabling stem cell therapies for tissue repair: current and future challenges.Biotechnology advancesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent advances in stem cell research have highlighted the role played by such cells and their environment (the stem cell niche) in tissue renewal and homeostasis. The control and regulation of stem cells and their niche are remaining challenges for cell therapy and regenerative medicine on several tissues and organs. These advances are important for both, the basic knowledge of stem cell regulation, and their practical translational applications into clinical medicine. This article is primarily concerned with the mesenchymal stem cells (MSCs) and it reviews the current aspects of their own niche. We discuss on the need for a deeper understanding of the identity of this cell type and its microenvironment in order to improve the effectiveness of any cell therapy for regenerative medicine. Ex vivo reproduction of the conditions of the natural stem cell niche, when necessary, would provide success to tissue engineering. The first challenge of regenerative medicine is to find cells able to replace and/or repair the lost function of tissues and organs by disease or aging and the trophic and immunomodulatory effects recently found for MSCs open up for new opportunities. If MSCs are pericytes, as it has been proposed, perhaps it may explain the ubiquity of these cells and their possible role in miscellaneous repairs throughout the body opening for new chances for extensive tissue repair.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.