ReviewForensic science, medicine, and pathology2011
Review: Pharmacogenetic aspects of the effect of cytochrome P450 polymorphisms on serotonergic drug metabolism, response, interactions, and adverse effects.
Review in Forensic science, medicine, and pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 71 citations in OpenAlex.
- PXR polymorphisms and their impact on pharmacokinetics/pharmacodynamics of repaglinide in healthy Chinese volunteers.European journal of clinical pharmacology · 2013Trial
- Genes, Cognition, and Their Interplay in Methamphetamine Use Disorder.Biomolecules · 2025Review
- Article
- Novel deep learning-based transcriptome data analysis for drug-drug interaction prediction with an application in diabetes.BMC bioinformatics · 2021Article
- Serotonin syndrome: SSRIs are not the only culprit.Journal of psychiatry & neuroscience : JPN · 2021Article
- Effects of Avitinib on CYP450 Enzyme Activity in vitro and in vivo in Rats.Drug design, development and therapy · 2021Article
- Serotonin syndrome in the perioperative period.BJA education · 2020Review
- Noradrenergic Mechanisms in Fentanyl-Mediated Rapid Death Explain Failure of Naloxone in the Opioid Crisis.The Journal of pharmacology and experimental therapeutics · 2019Review
- A Systems Biology Approach for Personalized Medicine in Refractory Epilepsy.International journal of molecular sciences · 2019Review
- Fatal intoxication with antidepressants: a case with many culprits.Forensic science, medicine, and pathology · 2018Article
- Codeine Precipitating Serotonin Syndrome in a Patient in Therapy with Antidepressant and Triptan.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2017Article
- Histopathological study of cardiac lesions in methamphetamine poisoning-related deaths.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2017Article
- Drug Interaction and Serotonin Toxicity with Opioid Use: Another Reason to Avoid Opioids in Headache and Migraine Treatment.Current pain and headache reports · 2016Review
- Interaction of different antidepressants with acute and chronic methadone in mice, and possible clinical implications.Journal of molecular neuroscience : MN · 2014Article
- Cases of adverse reaction to psychotropic drugs and possible association with pharmacogenetics.Journal of personalized medicine · 2012Article
- The role of toxicology interpretations in prevention of sudden death.Forensic science, medicine, and pathology · 2012Article
- The impact of 2011!Forensic science, medicine, and pathology · 2012Article
- Statistical Optimization of Pharmacogenomics Association Studies: Key Considerations from Study Design to Analysis.Current pharmacogenomics and personalized medicine · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The field of pharmacogenetics contains a wealth of potential for the enhancement of clinical practice by providing a more effective match between patient and drug, consequently reducing the probability of an adverse drug reaction. Although a relatively novel concept in the forensic context, pharmacogenetics has the capability to assist in the interpretation of drug related deaths, particularly in unintentional drug poisonings where the cause of death remains unclear. However, the complex pharmacology of the drugs when subjected to genetic variations in metabolism makes interpretation of the expected response and adverse events difficult. Many possess multiple metabolic pathways, narrow therapeutic indices and active metabolites or enantiomers which may be eliminated via different pathways to the parent drug. A number of these drugs, which are metabolised primarily by the CYP450 system, are also associated with serotonin syndrome, or serotonin toxicity, especially when used concomitantly with other serotonin active drugs which rely on the same metabolic pathways for drug elimination. A comprehensive understanding of polymorphic drug metabolism and its expected outcomes is therefore essential when interpreting the involvement of drugs in adverse reactions. This review examines the genetically variable CYP450-mediated metabolism of a number of serotonin-active drugs that are often implicated in cases of serotonin toxicity, to assess the impact of pharmacogenetics on drug metabolism, response, interactions and adverse effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.