ArticleIrish journal of medical science2011
Periconceptional folic acid prevents miscarriage in Irish families with neural tube defects.
Article in Irish journal of medical science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Association between gene polymorphism of folate metabolism and recurrent spontaneous abortion in Asia: A Meta-analysis.Medicine · 2020Pooled it
- Trial
- Prevention of congenital malformations and other adverse pregnancy outcomes with 4.0 mg of folic acid: community-based randomized clinical trial in Italy and the Netherlands.BMC pregnancy and childbirth · 2014Trial
- Association of spontaneous abortion with dietary folate intake in individuals with different genotypes of FTO gene.BMC pregnancy and childbirth · 2025Article
- Folic Acid Fortification Prevents Morphological and Behavioral Consequences of X-Ray Exposure During Neurulation.Frontiers in behavioral neuroscience · 2020Article
- Maternal hyperglycemia disturbs neocortical neurogenesis via epigenetic regulation in C57BL/6J mice.Cell death & disease · 2019Article
- Increasing the Chances of Natural Conception: Opinion Statement from the the Brazilian Federation of Gynecology and Obstetrics Associations - FEBRASGO - Committee of Gynecological Endocrinology.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2019Article
- Diet and fertility: a review.American journal of obstetrics and gynecology · 2018Review
- Association between serum folate and vitamin B-12 and outcomes of assisted reproductive technologies.The American journal of clinical nutrition · 2015Observational
- Prepregnancy Nutrition and Early Pregnancy Outcomes.Current nutrition reports · 2015Article
- Folic acid supplementation in pregnancy and implications in health and disease.Journal of biomedical science · 2014Review
- Maternal prepregnancy folate intake and risk of spontaneous abortion and stillbirth.Obstetrics and gynecology · 2014Article
- Three generations of matrilineal excess of birth defects in Irish families with neural tube defects.Irish journal of medical science · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMiscarriages occur to excess in sibships with neural tube defects (NTDs) and among maternal versus paternal relatives in NTD families. Folic acid prevents most NTDs. Its potential to prevent miscarriages has been controversial.
aimWe evaluated the relationship of maternal line and periconceptional folic acid with miscarriage.
methodsFirst cousins in Irish families with NTDs were interviewed about pregnancy outcomes and the health of their offspring.
resultsMiscarriages were not more frequent among pregnancies of maternal versus paternal first cousins. Folic acid intake during early pregnancy significantly reduced the risk of miscarriage from 15.7 to 9.6%, for an adjusted odds ratio of 0.37 (95% confidence interval 0.19, 0.72, p = 0.005).
conclusionsFolic acid during pregnancy was associated with a reduction of approximately 60% in miscarriages. Miscarriages are common-one in every eight pregnancies in this study. If incorporated into pre-pregnancy counseling, these results could have significant public health impact.
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Registered trials
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