ReviewFunctional & integrative genomics2011
Structure, function, and engineering of enzymes in isoflavonoid biosynthesis.
Review in Functional & integrative genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 81 citations in OpenAlex.
- Targeted expression of Glycine max isoflavone synthase enhances daidzein and genistein content in soybean.Transgenic research · 2026Article
- Efficient, complete biosynthesis of isoflavonoid calycosin-7-glucoside by metabolically engineered yeast cell factories.Frontiers in bioengineering and biotechnology · 2026Article
- Transcription, Alternative Splicing, and Post-Translational Regulation of CaLOXs in the Dynamic Regulation of Jasmonate Levels in Wounded Pepper Leaves.Plants (Basel, Switzerland) · 2025Article
- The GmSTF1/2-GmBBX4 negative feedback loop acts downstream of blue-light photoreceptors to regulate isoflavonoid biosynthesis in soybean.Plant communications · 2024Article
- Article
- Unraveling the serial glycosylation in the biosynthesis of steroidal saponins in the medicinal plantActa pharmaceutica Sinica. B · 2023Article
- Integrative Analysis of Metabolome and Transcriptome Reveals the Mechanism of Color Formation in Yellow-Fleshed Kiwifruit.International journal of molecular sciences · 2023Article
- Therapeutic Potential and Mechanisms of Novel Simple O-Substituted Isoflavones against Cerebral Ischemia Reperfusion.International journal of molecular sciences · 2022Review
- Transcriptomics and Metabolomics Analyses Reveal Defensive Responses and Flavonoid Biosynthesis ofMolecules (Basel, Switzerland) · 2022Article
- Biochemical and Molecular Characterization of the Rice Chalcone Isomerase Family.Plants (Basel, Switzerland) · 2021Article
- Flavonoids and Isoflavonoids Biosynthesis in the Model LegumePlants (Basel, Switzerland) · 2020Review
- Opinion on the Hurdles and Potential Health Benefits in Value-Added Use of Plant Food Processing By-Products as Sources of Phenolic Compounds.International journal of molecular sciences · 2018Review
- Phenylalanine ammonia-lyase2.1 contributes to the soybean response towards Phytophthora sojae infection.Scientific reports · 2017Article
- Comparative proteomic analysis of autotetraploid and diploidPhysiology and molecular biology of plants : an international journal of functional plant biology · 2017Article
- Isoflavones, their Glycosides and Glycoconjugates. Synthesis and Biological Activity.Current organic chemistry · 2017Review
- The Role of Flavonoids in Nodulation Host-Range Specificity: An Update.Plants (Basel, Switzerland) · 2016Review
- Methylation mediated by an anthocyanin, O-methyltransferase, is involved in purple flower coloration in Paeonia.Journal of experimental botany · 2015Article
- Article
- The impact of dietary isoflavonoids on malignant brain tumors.Cancer medicine · 2014Article
- Evolutionary study of the isoflavonoid pathway based on multiple copies analysis in soybean.BMC genetics · 2014Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Isoflavonoids are a large group of plant natural products and play important roles in plant defense. They also possess valuable health-promoting activities with significant health benefits for animals and humans. The isoflavonoids are identified primarily in leguminous plants and are synthesized through the central phenylpropanoid pathway and the specific isoflavonoid branch pathways in legumes. Structural studies of some key enzymes in the central phenylpropanoid pathway shed light on the early stages of the (iso)flavonoid biosynthetic process. Significant impact has also been made on structural studies of enzymes in the isoflavonoid branch pathways. Structures of isoflavonoid-specific NADPH-dependent reductases revealed how the (iso)flavonoid backbones are modified by reduction reactions and how enzymes specifically recognize isoflavonoids and catalyze stereo-specific reductions. Structural studies of isoflavonoid methyltransferases and glycosyltransferases revealed how isoflavonoids are further decorated with methyl group and sugars in different methylation and glycosylation patterns that determine their bioactivities and functions. In combination with mutagenesis and biochemical studies, the detailed structural information of these enzymes provides a basis for understanding the complex biosynthetic process, enzyme catalytic mechanisms, and substrate specificities. Structure-based homology modeling facilitates the functional characterization of these large groups of biosynthetic enzymes and their homologs. Structure-based enzyme engineering is becoming a new strategy for synthesis of bioactive isoflavonoids and also facilitates plant metabolic engineering towards improvement of quality and production of crop plants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.