Evidence map›Paper›PMID 21052488›Full record

ReviewClinical & developmental immunology2011

Behçet's disease (Adamantiades-Behçet's disease).

Fumio Kaneko, Ari Togashi, Sanae Saito, Hideo Sakuma, Noritaka Oyama, Koichiro Nakamura, Kenji Yokota, Keiji Oguma

Open access · goldAbstract readReview
In one paragraph

Review in Clinical & developmental immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Epidemiology and treatment of Adamantiades-Behçet's disease in Germany: A healthcare claims database study.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025
    Article
  3. Can the mucosal attacks of Behçet's disease be predicted?Archives of dermatological research · 2024
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Expression of TNF-α, APRIL and BCMA in Behcet's disease.Journal of immunology research · 2014
    Article
  9. Review
  10. Oral manifestation in inflammatory bowel disease: a review.World journal of gastroenterology · 2013
    Review
  11. Article
  12. Article
  13. Behçet's disease in an adolescent patient.Annali di stomatologia · 2013
    Article
  14. Review
  15. New approaches in immunotherapy of behçet disease.Advanced pharmaceutical bulletin · 2013
    Article
  16. Article
  17. [Behçet's disease - ophthalmological and general aspects part I : etiology, pathogenesis and diagnostics].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2012
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Fumio KanekoInstitute of Dermato-Immunology and Allergy, Southern TOHOKU Research Institute for Neuroscience, 7-115 Yatsuyamada, Koriyama, Fukushima 963-8563, Japan. f.kaneko@mt.strins.or.jp
Ari Togashi
Sanae Saito
Hideo Sakuma
Noritaka Oyama
Koichiro Nakamura
Kenji Yokota
Keiji Oguma
Southern Tohoku General Hospital · JPOkayama University · JPFukushima Medical University · JPSaitama Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adamantiades-Behçet's disease (ABD) is characterized by starting with oral aphthous ulceration and developing of the systemic involvements. The pathogenesis of ABD is closely correlated with the genetic factors and the triggering factors which acquire delayed-type hypersensitivity reaction against oral streptococci mediated by IL-12 cytokine family. HLA-B51 is associated in more than 60% of the patients and its restricted CD8+ T cell response is clearly correlated with the target tissues. Bes-1 gene encoded partial S. sanguinis genome which is highly homologous with retinal protein, and 65 kD heat shock protein (Hsp-65) released from streptococci is playing an important role with human Hsp-60 in the pathogenesis of ABD. Although Hsp-65/60 has homologies with the respective T cell epitope, it stimulates peripheral blood mononuclear cells (PBMCs) from ABD patients. On the other hand, some peptides of Hsp-65 were found to reduce IL-8 and IL-12 production from PBMCs of ABD patients in active stage.

Indexed as

AnimalsAntigens, BacterialBehcet SyndromeCD8-Positive T-LymphocytesChaperonin 60Cross ReactionsHLA-B51 AntigenHLA-B AntigensHumansInterleukin-12Stomatitis, AphthousAntigens, BacterialBES-1 protein, Streptococcus sanguisChaperonin 60HLA-B51 AntigenHLA-B AntigensInterleukin-12

Identifiers

PMID21052488
PMCPMC2967828
OpenAlexW2005714449

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.