Evidence map›Paper›PMID 21051775›Full record

ArticleSystematic biology2011

Dating primate divergences through an integrated analysis of palaeontological and molecular data.

Richard D Wilkinson, Michael E Steiper, Christophe Soligo, Robert D Martin, Ziheng Yang, Simon Tavaré

Open access · bronzeAbstract read
In one paragraph

Article in Systematic biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 1 pooled it
28.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 1 synthesis or guideline pooled it, 219 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Parting ways: Pan-Homo divergence revisited.Primates; journal of primatology · 2026
    Review
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  7. The Earliest Known Radiation of Pitheciine Primates.American journal of primatology · 2025
    Review
  8. Birth and death processes in phylogenetics and population genetics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  9. Article
  10. Article
  11. An improved assembly of the "Cascade" hop (Horticulture research · 2023
    Article
  12. Predicting Archaic Hominin Phenotypes from Genomic Data.Annual review of genomics and human genetics · 2022
    Review
  13. Dating Microbial Evolution with MCMCtree.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  14. Article
  15. Quest for the Best Evolutionary Model.Journal of molecular evolution · 2021
    Article
  16. Article
  17. Article
  18. Organization of extrastriate and temporal cortex in chimpanzees compared to humans and macaques.Cortex; a journal devoted to the study of the nervous system and behavior · 2019
    Article
  19. Article
  20. Article

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Richard D WilkinsonSchool of Mathmatical Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK. r.d.wilkinson@nottingham.ac.uk
Michael E Steiper
Christophe Soligo
Robert D Martin
Ziheng Yang
Simon Tavaré
University College London · GBField Museum of Natural History · USNew York Consortium in Evolutionary Primatology · USUniversity of Cambridge · GBUniversity of Nottingham · GB

Funding

Biotechnology and Biological Sciences Research CouncilNCRR NIH HHS RR03037
6 · The paper itself

Abstract

Estimation of divergence times is usually done using either the fossil record or sequence data from modern species. We provide an integrated analysis of palaeontological and molecular data to give estimates of primate divergence times that utilize both sources of information. The number of preserved primate species discovered in the fossil record, along with their geological age distribution, is combined with the number of extant primate species to provide initial estimates of the primate and anthropoid divergence times. This is done by using a stochastic forwards-modeling approach where speciation and fossil preservation and discovery are simulated forward in time. We use the posterior distribution from the fossil analysis as a prior distribution on node ages in a molecular analysis. Sequence data from two genomic regions (CFTR on human chromosome 7 and the CYP7A1 region on chromosome 8) from 15 primate species are used with the birth-death model implemented in mcmctree in PAML to infer the posterior distribution of the ages of 14 nodes in the primate tree. We find that these age estimates are older than previously reported dates for all but one of these nodes. To perform the inference, a new approximate Bayesian computation (ABC) algorithm is introduced, where the structure of the model can be exploited in an ABC-within-Gibbs algorithm to provide a more efficient analysis.

Indexed as

Biological EvolutionFossilsAnimalsBayes TheoremEvolution, MolecularHumansMarkov ChainsMonte Carlo MethodPaleontologyPhylogenyPrimates

Identifiers

PMID21051775
PMCPMC2997628
OpenAlexW2167933455

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.