ArticleHuman molecular genetics2011
PCSK6 is associated with handedness in individuals with dyslexia.
Article in Human molecular genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
56 citing papers in PubMed, 4 syntheses or guidelines pooled it, 139 citations in OpenAlex.
- A Genome-Wide Association Study of Prediabetes Status Change.Frontiers in endocrinology · 2022Pooled it
- Genome-wide association study identifies 48 common genetic variants associated with handedness.Nature human behaviour · 2021Pooled it
- Four meta-analyses across 164 studies on atypical footedness prevalence and its relation to handedness.Scientific reports · 2020Pooled it
- Common variants in left/right asymmetry genes and pathways are associated with relative hand skill.PLoS genetics · 2013Pooled it
- Non-right-handedness and psychiatric disorders: A synthesis of epidemiological, genetic, and neurobiological evidence.World journal of psychiatry · 2026Review
- Handedness in schizophrenia and affective disorders: a large-scale cross-disorder study.European archives of psychiatry and clinical neuroscience · 2025Article
- Single-nucleus multi-omics analyses reveal cellular and molecular innovations in the anterior cingulate cortex during primate evolution.Cell genomics · 2024Article
- Clinical implications of brain asymmetries.Nature reviews. Neurology · 2024Review
- A deep phenotyping approach to assess the association of handedness, early life factors and mental health.Scientific reports · 2023Article
- Polygenic scores for handedness and their association with asymmetries in brain structure.Brain structure & function · 2022Article
- Mouse Models of Human Proprotein Convertase Insufficiency.Endocrine reviews · 2021Review
- Quantitative genome-wide association analyses of receptive language in the Danish High Risk and Resilience Study.BMC neuroscience · 2020Article
- Prevalence and heritability of handedness in a Hong Kong Chinese twin and singleton sample.BMC psychology · 2020Article
- Different laterality indexes are poorly correlated with one another but consistently show the tendency of males and females to be more left- and right-lateralized, respectively.Royal Society open science · 2020Article
- Quantitative In vivo MRI Assessment of Structural Asymmetries and Sexual Dimorphism of Transient Fetal Compartments in the Human Brain.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Structural Asymmetry in the Frontal and Temporal Lobes Is Associated with PCSK6 VNTR Polymorphism.Molecular neurobiology · 2019Article
- Handedness, language areas and neuropsychiatric diseases: insights from brain imaging and genetics.Brain : a journal of neurology · 2019Article
- The molecular genetics of hand preference revisited.Scientific reports · 2019Article
- A large-scale population study of early life factors influencing left-handedness.Scientific reports · 2019Article
- Building an Asymmetrical Brain: The Molecular Perspective.Frontiers in psychology · 2019Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Approximately 90% of humans are right-handed. Handedness is a heritable trait, yet the genetic basis is not well understood. Here we report a genome-wide association study for a quantitative measure of relative hand skill in individuals with dyslexia [reading disability (RD)]. The most highly associated marker, rs11855415 (P = 4.7 × 10(-7)), is located within PCSK6. Two independent cohorts with RD show the same trend, with the minor allele conferring greater relative right-hand skill. Meta-analysis of all three RD samples is genome-wide significant (n = 744, P = 2.0 × 10(-8)). Conversely, in the general population (n = 2666), we observe a trend towards reduced laterality of hand skill for the minor allele (P = 0.0020). These results provide molecular evidence that cerebral asymmetry and dyslexia are linked. Furthermore, PCSK6 is a protease that cleaves the left-right axis determining protein NODAL. Functional studies of PCSK6 promise insights into mechanisms underlying cerebral lateralization and dyslexia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.