ArticleJournal of the American Society of Nephrology : JASN2010
Minocycline protects against neurologic complications of rapid correction of hyponatremia.
Article in Journal of the American Society of Nephrology : JASN, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 30 citations in OpenAlex.
- Adaptation of the Brain to Hyponatremia and Its Clinical Implications.Journal of clinical medicine · 2023Review
- Osmotic Demyelination Syndrome Associated with Hypernatremia Caused by Lactulose Enema in a Patient with Chronic Alcoholism.Electrolyte & blood pressure : E & BP · 2021Article
- Article
- Osmotic Demyelination: From an Oligodendrocyte to an Astrocyte Perspective.International journal of molecular sciences · 2019Review
- Hyponatremia in the intensive care unit: How to avoid a Zugzwang situation?Annals of intensive care · 2015Article
- Neurological counterparts of hyponatremia: pathological mechanisms and clinical manifestations.Current neurology and neuroscience reports · 2015Review
- Clinical management of SIADH.Therapeutic advances in endocrinology and metabolism · 2012Article
- Extrapontine myelinolysis of osmotic demyelination syndrome in a case of postoperative suprasellar arachnoid cyst.Case reports in medicine · 2012Article
- Astrocytes are an early target in osmotic demyelination syndrome.Journal of the American Society of Nephrology : JASN · 2011Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osmotic demyelination syndrome is a devastating neurologic condition that occurs after rapid correction of serum sodium in patients with hyponatremia. Pathologic features of this injury include a well-demarcated region of myelin loss, a breakdown of the blood-brain barrier, and infiltration of microglia. The semisynthetic tetracycline minocycline is protective in some animal models of central nervous system injury, including demyelination, suggesting that it may also protect against demyelination resulting from rapid correction of chronic hyponatremia. Using a rat model of osmotic demyelination syndrome, we found that treatment with minocycline significantly decreases brain demyelination, alleviates neurologic manifestations, and reduces mortality associated with rapid correction of hyponatremia. Mechanistically, minocycline decreased the permeability of the blood-brain barrier, inhibited microglial activation, decreased both the expression of IL1α and protein nitrosylation, and reduced the loss of GFAP immunoreactivity. In conclusion, minocycline modifies the course of osmotic demyelination in rats, suggesting its possible therapeutic use in the setting of inadvertent rapid correction of chronic hyponatremia in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.