ArticleInvestigative ophthalmology & visual science2011
The Streptococcus pneumoniae capsule is required for full virulence in pneumococcal endophthalmitis.
Article in Investigative ophthalmology & visual science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 37 citations in OpenAlex.
- Wzi modulates immune evasion of hypervirulentVirulence · 2026Article
- High-resolution genomics uncovers region-specific evolution and virulence of ocularMicrobiology spectrum · 2026Article
- Pathogen-Associated Visual Outcomes Following Postprocedure Endophthalmitis.American journal of ophthalmology · 2026Article
- Article
- Bacterial capsules: Occurrence, mechanism, and function.NPJ biofilms and microbiomes · 2024Review
- Ocular Bacterial Infections: A Ten-Year Survey and Review of Causative Organisms Based on the Oklahoma Experience.Microorganisms · 2023Article
- Update on Current Microbiological Techniques for Pathogen Identification in Infectious Endophthalmitis.International journal of molecular sciences · 2022Review
- Article
- Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis.Journal of visualized experiments : JoVE · 2021Article
- Plant-Based Phytochemicals as Possible Alternative to Antibiotics in Combating Bacterial Drug Resistance.Antibiotics (Basel, Switzerland) · 2020Review
- The cereus matter of Bacillus endophthalmitis.Experimental eye research · 2020Review
- A Pyrrhic Victory: The PMN Response to Ocular Bacterial Infections.Microorganisms · 2019Review
- Targets of immunomodulation in bacterial endophthalmitis.Progress in retinal and eye research · 2019Review
- A Transcriptional Activator of Ascorbic Acid Transport inMicroorganisms · 2019Article
- Culture-Proven Endophthalmitis After Intravitreal Injection: A 10-Year Analysis.Ophthalmic surgery, lasers & imaging retina · 2019Article
- The Role of Pneumococcal Virulence Factors in Ocular Infectious Diseases.Interdisciplinary perspectives on infectious diseases · 2018Review
- Observational
- Bacterial and Fungal Endophthalmitis.Clinical microbiology reviews · 2017Review
- Exogenous Streptococcus pneumoniae Endophthalmitis in Diabetic Rabbits.Scientific reports · 2017Article
- Modeling intraocular bacterial infections.Progress in retinal and eye research · 2016Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo determine whether Streptococcus pneumoniae capsule was necessary for pathogenesis of pneumococcal endophthalmitis.
methodsAn isogenic capsule-deficient strain was created using homologous recombination. New Zealand White rabbits were injected intravitreously with 10(2) colony-forming units (CFU) of the parent strain or the capsule mutant. Slit lamp examination (SLE), electroretinography, and myeloperoxidase activity were performed 24 and 48 hours postinfection (PI). Serial dilutions of vitreous were plated to quantitate CFU, eyes were extracted for histology, and host cytokine mRNA expression was determined.
resultsEyes infected with the parent strain had significantly higher SLE scores than eyes infected with the capsule-deficient strain 24 and 48 hours PI (P < 0.001). CFU recovered from eyes infected with the capsule mutant were significantly fewer than CFU recovered from eyes infected with the parent strain 24 and 48 hours PI (P < 0.001). The parent strain caused a significantly greater decrease in retinal function and more retinal destruction than the mutant strain 48 hours PI (P = 0.026). Vitreal IL-1β, IL-6, and TNF-α were upregulated by both the parent and mutant strain 12 hours PI. By 48 hours PI, there was significantly more neutrophil infiltration in the vitreous infected with the parent strain.
conclusionsEndophthalmitis caused by the encapsulated strain is more damaging to retinal function and structural integrity. These findings indicate that capsule is an important virulence factor of S. pneumoniae endophthalmitis, in contrast to keratitis, suggesting that the anatomic host site in pneumococcal ocular infections is important.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.