ArticleThe Journal of biological chemistry2011
Slowly produced microRNAs control protein levels.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Dissipatively Fueled Unidirectionally Communicating DNA Circuits That Control Biocatalysis.Angewandte Chemie (International ed. in English) · 2026Article
- Understanding microRNA-mediated gene regulatory networks through mathematical modelling.Nucleic acids research · 2016Article
- An evolutionarily biased distribution of miRNA sites toward regulatory genes with high promoter-driven intrinsic transcriptional noise.BMC evolutionary biology · 2014Article
- Article
- Origins of binary gene expression in post-transcriptional regulation by microRNAs.The European physical journal. E, Soft matter · 2012Article
- Loss of SHIP-1 protein expression in high-risk myelodysplastic syndromes is associated with miR-210 and miR-155.Oncogene · 2012Article
- Scanometric microRNA array profiling of prostate cancer markers using spherical nucleic acid-gold nanoparticle conjugates.Analytical chemistry · 2012Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Proteins are the primary agents of function in biological systems, and their levels are critical control elements, reflecting the interplay between transcription, translation, and protein degradation. Here, we consider the role of microRNAs (miRNAs) in the post-transcriptional regulation of protein synthesis. To determine their impact on protein concentration, we constructed a mechanistic model consisting of four state variables and nine kinetic parameters that account for transcript sequestration and degradation via miRNA-mRNA complex formation. Our dynamical model predicts that, even when present in low copy number, miRNAs can exert potent effects on protein concentration. Sensitivity analysis of the steady-state solution indicates that miRNA synthesis commonly acts to fine-tune protein concentrations. However, the same analysis shows that for a small subset of miRNA-mRNA pairs characterized by slowly produced miRNAs, the miRNA synthesis rate is the dominant control element. Our model equations provide a tool to evaluate the importance of particular miRNAs on their target proteins and promote the development of miRNA-based therapies that target proteins associated with cancer, inflammation, and metabolic disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.