ArticleCalcified tissue international1990
Long-term physical exercise retards trabecular bone loss in lumbar vertebrae of aging female mice.
Article in Calcified tissue international, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 46 citations in OpenAlex.
- Prevention of chemotherapy-related bone loss with doxorubicin-loaded solid lipid nanoparticles.Nanomedicine (London, England) · 2024Article
- Effect of regular resistance exercise, vitamin D, and calcium supplements on the bone mineral content and density in postmenopausal model of rats: An experimental study.International journal of reproductive biomedicine · 2021Article
- The effects of different intensities of exercise and active vitamin D on mouse bone mass and bone strength.Journal of bone and mineral metabolism · 2017Article
- Aged male rats regenerate cortical bone with reduced osteocyte density and reduced secretion of nitric oxide after mechanical stimulation.Calcified tissue international · 2014Article
- Connexin43 modulates post-natal cortical bone modeling and mechano-responsiveness.BoneKEy reports · 2013Article
- Tibial loading increases osteogenic gene expression and cortical bone volume in mature and middle-aged mice.PloS one · 2012Article
- Aged mice have enhanced endocortical response and normal periosteal response compared with young-adult mice following 1 week of axial tibial compression.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2010Article
- The effects of a 5-month physical training on iliac bone morphology in monkeys.European journal of applied physiology and occupational physiology · 1993Article
- Experimental changes in mineral content of juvenile mouse femora.Calcified tissue international · 1992Article
- Can vigorous exercise play a role in osteoporosis prevention? A review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 1992Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study examined the effect of long-term, moderate physical exercise on trabecular bone volume (TBV), calcium content, 3H-proline uptake, and the activities of alkaline and acid phosphatases in lumbar vertebrae of aging and senescent mice. It became apparent that if physical activity starts at an early stage of life, i.e., prior to middle age and is extended until old age, it exerts beneficial effects on trabecular bone mass and mineralization. Such a positive effect is not obtained if the training program is initiated after middle age. The training-induced reduction in bone loss was accompanied by a significant decrease in acid phosphatase activity whereas no changes took place with regard to the activity of alkaline phosphatase. Long-term physical exercise also enhanced the uptake of 3H-proline by lining cells along the bone trabecules. In spite of its moderate nature, the endured training program served as a stress factor for the involved animals, a fact that was manifested by an increase in the serum levels of corticosterone. Thus, it seems that whereas young animals respond favorably to such a stimulatory stress, older animals lose this ability of adaptation.
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