ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2011
In vivo analysis of mouse gastrin gene regulation in enhanced GFP-BAC transgenic mice.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Effect of netazepide, a gastrin/CCK2 receptor antagonist, on gastric acid secretion and rabeprazole-induced hypergastrinaemia in healthy subjects.British journal of clinical pharmacology · 2015Trial
- Effect of repeated doses of netazepide, a gastrin receptor antagonist, omeprazole and placebo on 24 h gastric acidity and gastrin in healthy subjects.British journal of clinical pharmacology · 2013Trial
- Netazepide, a gastrin/CCK2 receptor antagonist, causes dose-dependent, persistent inhibition of the responses to pentagastrin in healthy subjects.British journal of clinical pharmacology · 2013Trial
- Stomach gastrin is regulated by sodium via PPAR-α and dopamine D1 receptor.Journal of molecular endocrinology · 2020Article
- Mechanosensitive ion channel Piezo1 is expressed in antral G cells of murine stomach.Cell and tissue research · 2018Article
- Topographic distribution pattern of morphologically different G cells in the murine antral mucosa.European journal of histochemistry : EJH · 2017Article
- Identification of 5-hydroxytryptamine-producing cells by detection of fluorescence in paraffin-embedded tissue sections.European journal of histochemistry : EJH · 2016Article
- Islet Cells Serve as Cells of Origin of Pancreatic Gastrin-Positive Endocrine Tumors.Molecular and cellular biology · 2015Article
- Article
- Analysis of the protein related receptor GPR92 in G-cells.Frontiers in physiology · 2015Article
- Cholecystokinin and pancreatic cancer: the chicken or the egg?American journal of physiology. Gastrointestinal and liver physiology · 2014Review
- Overnutrition stimulates intestinal epithelium proliferation through β-catenin signaling in obese mice.Diabetes · 2013Article
- Gastrin: a distinct fate of neurogenin3 positive progenitor cells in the embryonic pancreas.PloS one · 2013Article
- Treatment with chicken-egg-white or whole-egg extracts maintains and enhances the survival and differentiation of spleen cells.Cytotechnology · 2012Article
- A high-fat diet regulates gastrin and acid secretion through primary cilia.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- Gastrointestinal chemosensation: chemosensory cells in the alimentary tract.Histochemistry and cell biology · 2012Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
Gastrin is secreted from a subset of neuroendocrine cells residing in the gastric antrum known as G cells, but low levels are also expressed in fetal pancreas and intestine and in many solid malignancies. Although past studies have suggested that antral gastrin is transcriptionally regulated by inflammation, gastric pH, somatostatin, and neoplastic transformation, the transcriptional regulation of gastrin has not previously been demonstrated in vivo. Here, we describe the creation of an enhanced green fluorescent protein reporter (mGAS-EGFP) mouse using a bacterial artificial chromosome that contains the entire mouse gastrin gene. Three founder lines expressed GFP signals in the gastric antrum and the transitional zone to the corpus. In addition, GFP(+) cells could be detected in the fetal pancreatic islets and small intestinal villi, but not in these organs of the adult mice. The administration of acid-suppressive reagents such as proton pump inhibitor omeprazole and gastrin/CCK-2 receptor antagonist YF476 significantly increased GFP signal intensity and GFP(+) cell numbers in the antrum, whereas these parameters were decreased by overnight fasting, octreotide (long-lasting somatostatin ortholog) infusion, and Helicobacter felis infection. GFP(+) cells were also detected in the anterior lobe of the pituitary gland and importantly in the colonic tumor cells induced by administration with azoxymethane and dextran sulfate sodium salt. This transgenic mouse provides a useful tool to study the regulation of mouse gastrin gene in vivo, thus contributing to our understanding of the mechanisms involved in transcriptional control of the gastrin gene.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.