ArticleMicrobiology (Reading, England)2011
Transcriptional response of Mycoplasma genitalium to osmotic stress.
Article in Microbiology (Reading, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Pathogenicity and virulence ofVirulence · 2022Review
- Impacts ofMicrobial genomics · 2022Article
- Identification and Characterization of the Neisseria gonorrhoeae MscS-Like Mechanosensitive Channel.Infection and immunity · 2018Article
- Insights into the Mechanisms of Basal Coordination of Transcription Using a Genome-Reduced Bacterium.Cell systems · 2016Article
- Functional characterization of the principal sigma factor RpoD of phytoplasmas via an in vitro transcription assay.Scientific reports · 2015Article
- A novel sigma factor reveals a unique regulon controlling cell-specific recombination in Mycoplasma genitalium.Nucleic acids research · 2015Article
- Development and utilization of a custom PCR array workflow: analysis of gene expression in mycoplasma genitalium and guinea pig (Cavia porcellus).Molecular biotechnology · 2015Article
- MG428 is a novel positive regulator of recombination that triggers mgpB and mgpC gene variation in Mycoplasma genitalium.Molecular microbiology · 2014Article
- Functional characterization of osmotically inducible protein C (MG_427) from Mycoplasma genitalium.Journal of bacteriology · 2014Article
- Is life unique?Life (Basel, Switzerland) · 2011Review
- Rational design of an artificial genetic switch: Co-option of the H-NS-repressed proU operon by the VirB virulence master regulator.Journal of bacteriology · 2011Article
- Transcriptional regulation of MG_149, an osmoinducible lipoprotein gene from Mycoplasma genitalium.Molecular microbiology · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Mycoplasma genitalium is the causative agent of non-gonococcal, chlamydia-negative urethritis in men and has been linked to reproductive tract disease syndromes in women. As with other mycoplasmas, M. genitalium lacks many regulatory genes because of its streamlined genome and total dependence on a parasitic existence. Therefore, it is important to understand how gene regulation occurs in M. genitalium, particularly in response to environmental signals likely to be encountered in vivo. In this study, we developed an oligonucleotide-based microarray to investigate transcriptional changes in M. genitalium following osmotic shock. Using a physiologically relevant osmolarity condition (0.3 M sodium chloride), we identified 39 upregulated and 72 downregulated genes. Of the upregulated genes, 21 were of unknown function and 15 encoded membrane-associated proteins. The majority of downregulated genes encoded enzymes involved in energy metabolism and components of the protein translation process. These data provide insights into the in vivo response of M. genitalium to hyperosmolarity conditions and identify candidate genes that may contribute to mycoplasma survival in the urogenital tract.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.