ReviewChest2010
Reducing iatrogenic risks: ICU-acquired delirium and weakness--crossing the quality chasm.
Review in Chest, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01413009 (Awakening-Breathing Coordination, Delirium Monitoring/Management & Early Mobility), which is not on this map. Cited by 91 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Awakening-Breathing Coordination, Delirium Monitoring/Management & Early Mobility (ABCDE) Protocol
Who cites it
91 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Interventions for preventing intensive care unit delirium in adults.The Cochrane database of systematic reviews · 2018Pooled it
- Association between ABCDE bundle compliance and long-term outcomes: a secondary longitudinal analysis.Intensive care medicine · 2026Trial
- Deprescribing in the Pharmacologic Management of Delirium: A Randomized Trial in the Intensive Care Unit.Journal of the American Geriatrics Society · 2019Trial
- Enteral versus intravenous approach for the sedation of critically ill patients: a randomized and controlled trial.Critical care (London, England) · 2019Trial
- Trial
- Effects of propofol on sleep quality in mechanically ventilated critically ill patients: a physiological study.Intensive care medicine · 2012Trial
- Beyond Survival: Lessons From a Research Journey in Critical Care Recovery Science.American journal of critical care : an official publication, American Association of Critical-Care Nurses · 2026Article
- Transcranial doppler assessment of preoperative cerebral blood flow velocity in cardiac surgery patients.Journal of clinical monitoring and computing · 2026Observational
- Effects of early rehabilitation with a physiatrist and a registered therapist operating acute rehabilitation in mechanically ventilated ICU patients: a prospective observational study.Frontiers in rehabilitation sciences · 2026Article
- De-escalation of critical care and prevention of iatrogenicity through a self-tracking daily rounding checklist.Frontiers in pediatrics · 2026Article
- Article
- The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2024.Journal of intensive care · 2025Article
- Creating a Culture of an Awake and Walking Intensive Care Unit: In-Hospital Strategies to Mitigate Post-Intensive Care Syndrome.Critical care clinics · 2025Review
- Delirium and Coronavirus Disease 2019: Looking Back, Moving Forward.Critical care nursing clinics of North America · 2024Review
- Article
- Patterns of interactions among ICU interprofessional teams: A prospective patient-shift-level survey approach.PloS one · 2024Article
- Decrease in the intensive care unit-acquired weakness with a multicomponent protocol implementation: A quasi-experimental clinical trialBiomedica : revista del Instituto Nacional de Salud · 2023Article
- Article
- Article
- Effect of Early Multidisciplinary Collaboration Combined with Cluster Strategy on Acquired Debilitating Syndrome in ICU of Patients with Acute Myocardial Infarction.Iranian journal of public health · 2022Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ICUs are experiencing an epidemic of patients with acute brain dysfunction (delirium) and weakness, both associated with increased mortality and long-term disability. These conditions are commonly acquired in the ICU and are often initiated or exacerbated by sedation and ventilation decisions and management. Despite > 10 years of evidence revealing the hazards of delirium, the quality chasm between current and ideal processes of care continues to exist. Monitoring of delirium and sedation levels remains inconsistent. In addition, sedation, ventilation, and physical therapy practices proven successful at reducing the frequency and severity of adverse outcomes are not routinely practiced. In this article, we advocate for the adoption and implementation of a standard bundle of ICU measures with great potential to reduce the burden of ICU-acquired delirium and weakness. Individual components of this bundle are evidence based and can help standardize communication, improve interdisciplinary care, reduce mortality, and improve cognitive and functional outcomes. We refer to this as the "ABCDE bundle," for awakening and breathing coordination, delirium monitoring, and exercise/early mobility. This evidence-based bundle of practices will build a bridge across the current quality chasm from the "front end" to the "back end" of critical care and toward improved cognitive and functional outcomes for ICU survivors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.