ArticleNucleic acids research2011
The pseudogenes of Mycobacterium leprae reveal the functional relevance of gene order within operons.
Article in Nucleic acids research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
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- Decoding the similarities and differences among mycobacterial species.PLoS neglected tropical diseases · 2017Article
- Uncovering major genomic features of essential genes in Bacteria and a methanogenic Archaea.The FEBS journal · 2015Article
- Gene-pseudogene evolution: a probabilistic approach.BMC genomics · 2015Article
- SEED servers: high-performance access to the SEED genomes, annotations, and metabolic models.PloS one · 2012Article
- PromBase: a web resource for various genomic features and predicted promoters in prokaryotic genomes.BMC research notes · 2011Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Almost 50 years following the discovery of the prokaryotic operon, the functional relevance of gene order within operons remains unclear. In this work, we take advantage of the eroded genome of Mycobacterium leprae to add evidence supporting the notion that functionally less important genes have a tendency to be located at the end of its operons. M. leprae's genome includes 1133 pseudogenes and 1614 protein-coding genes and can be compared with the close genome of M. tuberculosis. Assuming M. leprae's pseudogenes to represent dispensable genes, we have studied the position of these pseudogenes in the operons of M. leprae and of their orthologs in M. tuberculosis. We observed that both tend to be located in the 3' (downstream) half of the operon (P-values of 0.03 and 0.18, respectively). Analysis of pseudogenes in all available prokaryotic genomes confirms this trend (P-value of 7.1 × 10(-7)). In a complementary analysis, we found a significant tendency for essential genes to be located at the 5' (upstream) half of the operon (P-value of 0.006). Our work provides an indication that, in prokarya, functionally less important genes have a tendency to be located at the end of operons, while more relevant genes tend to be located toward operon starts.
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