ArticlePsychiatry research2010
Structural equation modeling and principal component analysis of gray matter volumes in major depressive and bipolar disorders: differences in latent volumetric structure.
Article in Psychiatry research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
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- Principal component analysis as an efficient method for capturing multivariate brain signatures of complex disorders-ENIGMA study in people with bipolar disorders and obesity.Human brain mapping · 2024Article
- Impact of Stress on Brain Morphology: Insights into Structural Biomarkers of Stress-related Disorders.Current neuropharmacology · 2024Review
- Regions with Altered Degree Centrality and Their Functional Connectivity in First-Episode Drug-Naïve Major Depressive Disorder: A Resting-State Functional Magnetic Resonance Imaging Study.Alpha psychiatry · 2023Article
- Prolonged Longitudinal Transcutaneous Auricular Vagus Nerve Stimulation Effect on Striatal Functional Connectivity in Patients with Major Depressive Disorder.Brain sciences · 2022Article
- Novel Gyrification Networks Reveal Links with Psychiatric Risk Factors in Early Illness.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Immediate Modulation of Transcutaneous Auricular Vagus Nerve Stimulation in Patients With Treatment-Resistant Depression: A Resting-State Functional Magnetic Resonance Imaging Study.Frontiers in psychiatry · 2022Article
- Exploratory factor analysis with structured residuals for brain network data.Network neuroscience (Cambridge, Mass.) · 2021Article
- Common and Specific Characteristics of Adolescent Bipolar Disorder Types I and II: A Combined Cortical Thickness and Structural Covariance Analysis.Frontiers in psychiatry · 2021Article
- Brief Mindfulness Meditation Induces Gray Matter Changes in a Brain Hub.Neural plasticity · 2020Article
- Brain structure alterations in depression: Psychoradiological evidence.CNS neuroscience & therapeutics · 2018Review
- Age sensitive associations of adolescent substance use with amygdalar, ventral striatum, and frontal volumes in young adulthood.Drug and alcohol dependence · 2018Article
- Principal component analysis of early alcohol, drug and tobacco use with major depressive disorder in US adults.Journal of psychiatric research · 2018Article
- Neurobehavioral Mechanisms of Resilience Against Emotional Distress: An Integrative Brain-Personality-Symptom Approach Using Structural Equation Modeling.Personality neuroscience · 2018Article
- Alternations of White Matter Structural Networks in First Episode Untreated Major Depressive Disorder with Short Duration.Frontiers in psychiatry · 2017Article
- The volumetric and shape changes of the putamen and thalamus in first episode, untreated major depressive disorder.NeuroImage. Clinical · 2016Article
- Correlations between brain structure and symptom dimensions of psychosis in schizophrenia, schizoaffective, and psychotic bipolar I disorders.Schizophrenia bulletin · 2015Article
- Postconcussional disorder and PTSD symptoms of military-related traumatic brain injury associated with compromised neurocircuitry.Human brain mapping · 2014Article
- Reduced intrinsic connectivity of amygdala in adults with major depressive disorder.Frontiers in psychiatry · 2014Article
- Imaging structural co-variance between human brain regions.Nature reviews. Neuroscience · 2013Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Abnormalities of the cortico-striatal-thalamic-cortical (CSTC) and the limbic-cortico-striatal-thalamic-cortical (LCSTC) circuits have been hypothesized in mood disorders. We performed principal component analysis (PCA) to identify latent volumetric systems on regional brain volumes and correlated these patterns with clinical characteristics; further, we performed exploratory structural equation modeling (SEM) to test a priori hypotheses about the organization among the structures comprising the CSTC and LCSTC circuits, and to investigate differences among subjects with bipolar disorder (BD), major depressive disorder (MDD), and healthy controls (HC). Participants included 45 BD and 31 MDD patients, and 72 HC. Regional MR brain volumes were used to calculate patterns of volumetric covariance. The identified latent volumetric systems were related to the depression severity and the duration of illness. BD differed from HC on the estimated parameters describing the paths of cortico-striatal, thalamo-striatal and intrastriatal loops of the CSTC circuit, and the paths between anterior and posterior cingulate cortex (PCC), and hippocampus to amygdala of the LCSTC circuit. MDD differed from HC on the paths between putamen and thalamus, and PCC to hippocampus. This study provides evidence to suggest different organizational patterns among structures within the CSTC and LCSTC circuits for BD, MDD, and HC, which may point to structural abnormalities underlying mood disorders.
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Registered trials
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