ArticleThe Journal of infectious diseases2010
Characterization of the meiosis-specific recombinase Dmc1 of pneumocystis.
Article in The Journal of infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Retracing the evolution ofMicrobiology and molecular biology reviews : MMBR · 2024Review
- Pneumocystis Mating-Type Locus and Sexual Cycle during Infection.Microbiology and molecular biology reviews : MMBR · 2021Review
- Cryptococcus neoformans: Sex, morphogenesis, and virulence.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2021Review
- Life Cycle ofAnnual review of microbiology · 2019Review
- Characterization of p57, a Stage-Specific Antigen of Pneumocystis murina.The Journal of infectious diseases · 2018Article
- Article
- Article
- Pneumocystis encodes a functional endo-β-1,3-glucanase that is expressed exclusively in cysts.The Journal of infectious diseases · 2015Article
- Article
- Expression of Pneumocystis jirovecii major surface glycoprotein in Saccharomyces cerevisiae.The Journal of infectious diseases · 2013Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
The life cycle of Pneumocystis, which causes life-threatening pneumonia in immunosuppressed patients, remains poorly defined. In the present study, we have identified and characterized an orthologue of dmc1, a gene specific for meiotic recombination in yeast, in 3 species of Pneumocystis. dmc1 is a single-copy gene that is transcribed as ∼1.2-kb messenger RNA, which encodes a protein of 336-337 amino acids. Pneumocystis Dmc1 was 61%-70% identical to those from yeast. Confocal microscopy results indicated that the expression of Dmc1 is primarily confined to the cyst form of Pneumocystis. By sequence analysis of 2 single-copy regions of the human Pneumocystis jirovecii genome, we can infer multiple recombination events, which are consistent with meiotic recombination in this primarily haploid organism. Taken together, these studies support the occurrence of a sexual phase in the life cycle of Pneumocystis.
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Registered trials
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