ArticlePLoS neglected tropical diseases2010
Viral etiology of encephalitis in children in southern Vietnam: results of a one-year prospective descriptive study.
Article in PLoS neglected tropical diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 2 of them syntheses that pooled it.
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Who cites it
65 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Review of the aetiologies of central nervous system infections in Vietnam.Frontiers in public health · 2024Pooled it
- Estimates of Japanese Encephalitis mortality and morbidity: A systematic review and modeling analysis.PLoS neglected tropical diseases · 2022Pooled it
- Detection of central nervous system viral infections in adults in Manado, North Sulawesi, Indonesia.PloS one · 2018Trial
- A preliminary randomized double blind placebo-controlled trial of intravenous immunoglobulin for Japanese encephalitis in Nepal.PloS one · 2015Trial
- Novel and predominant pathogen responsible for the enterovirus-associated encephalitis in eastern China.PloS one · 2013Trial
- Valacyclovir for herpes simplex encephalitis.Antimicrobial agents and chemotherapy · 2011Trial
- Molecular and serological characterization of SARS-CoV-2 strains associated with viral encephalitis in Senegal during the COVID-19 pandemic.New microbes and new infections · 2026Article
- Review
- Article
- In Children,Open forum infectious diseases · 2024Article
- Review
- Global Landscape of Encephalitis: Key Priorities to Reduce Future Disease Burden.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Review
- The Worldwide Prevalence of Herpes Simplex Virus Encephalitis and Meningitis: A Systematic Review and Meta-Analysis.Turkish archives of pediatrics · 2023Article
- The spatio-temporal distribution of acute encephalitis syndrome and its association with climate and landcover in Vietnam.BMC infectious diseases · 2023Article
- Knowledge and attitudes toward complete diagnostic autopsy and minimally invasive autopsy: A cross-sectional survey in Hanoi, Vietnam.PLOS global public health · 2023Article
- Aetiology and Potential Animal Exposure in Central Nervous System Infections in Vietnam.EcoHealth · 2022Article
- Outbreak of central nervous system infections among children in Thai Binh, Viet Nam.Emerging microbes & infections · 2022Article
- Inconsistency analysis between metagenomic next-generation sequencing results of cerebrospinal fluid and clinical diagnosis with suspected central nervous system infection.BMC infectious diseases · 2022Article
- Observational
- Article
5 more citing papers are in PubMed but not listed here.
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16 authors.
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Abstract
backgroundAcute encephalitis is an important and severe disease in children in Vietnam. However, little is known about the etiology while such knowledge is essential for optimal prevention and treatment. To identify viral causes of encephalitis, in 2004 we conducted a one-year descriptive study at Children's Hospital Number One, a referral hospital for children in southern Vietnam including Ho Chi Minh City. METHODOLOGY/PRINCIPAL
findingsChildren less than 16 years of age presenting with acute encephalitis of presumed viral etiology were enrolled. Diagnostic efforts included viral culture, serology and real time (RT)-PCRs. A confirmed or probable viral causative agent was established in 41% of 194 enrolled patients. The most commonly diagnosed causative agent was Japanese encephalitis virus (n = 50, 26%), followed by enteroviruses (n = 18, 9.3%), dengue virus (n = 9, 4.6%), herpes simplex virus (n = 1), cytomegalovirus (n = 1) and influenza A virus (n = 1). Fifty-seven (29%) children died acutely. Fatal outcome was independently associated with patient age and Glasgow Coma Scale (GCS) on admission. CONCLUSIONS/SIGNIFICANCE: Acute encephalitis in children in southern Vietnam is associated with high mortality. Although the etiology remains unknown in a majority of the patients, the result from the present study may be useful for future design of treatment and prevention strategies of the disease. The recognition of GCS and age as predictive factors may be helpful for clinicians in managing the patient.
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