ArticlePloS one2010
Fluoxetine treatment abolishes the in vitro respiratory response to acidosis in neonatal mice.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- Serotonin and the ventilatory effects of etonogestrel, a gonane progestin, in a murine model of congenital central hypoventilation syndrome.Frontiers in endocrinology · 2023Article
- Article
- Article
- Fluoxetine augments ventilatory CO2 sensitivity in Brown Norway but not Sprague Dawley rats.Respiratory physiology & neurobiology · 2013Article
- Gestational stress promotes pathological apneas and sex-specific disruption of respiratory control development in newborn rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- The vesicular glutamate transporter VGLUT3 contributes to protection against neonatal hypoxic stress.The Journal of physiology · 2012Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo secure pH homeostasis, the central respiratory network must permanently adapt its rhythmic motor drive to environment and behaviour. In neonates, it is commonly admitted that the retrotrapezoid/parafacial respiratory group of neurons of the ventral medulla plays the primary role in the respiratory response to acidosis, although the serotonergic system may also contribute to this response. METHODOLOGY/PRINCIPAL
findingsUsing en bloc medullary preparations from neonatal mice, we have shown for the first time that the respiratory response to acidosis is abolished after pre-treatment with the serotonin-transporter blocker fluoxetine (25-50 µM, 20 min), a commonly used antidepressant. Using mRNA in situ hybridization and immunohistology, we have also shown the expression of the serotonin transporter mRNA and serotonin-containing neurons in the vicinity of the RTN/pFRG of neonatal mice.
conclusionsThese results reveal that the serotonergic system plays a pivotal role in pH homeostasis. Although obtained in vitro in neonatal mice, they suggest that drugs targeting the serotonergic system should be used with caution in infants, pregnant women and breastfeeding mothers.
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Registered trials
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