Evidence map›Paper›PMID 21048971›Full record

ArticlePloS one2010

Common SNPs in myelin transcription factor 1-like (MYT1L): association with major depressive disorder in the Chinese Han population.

Ti Wang, Zhen Zeng, Tao Li, Jie Liu, Junyan Li, You Li, Qian Zhao, Zhiyun Wei, Yang Wang, Baojie Li and 3 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 30 citations in OpenAlex.

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  8. Methylomic analysis of salivary DNA in childhood ADHD identifies altered DNA methylation in VIPR2.Journal of child psychology and psychiatry, and allied disciplines · 2016
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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Ti WangBio-X Center and Affiliated Changning Mental Health Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Zhen Zeng
Tao Li
Jie Liu
Junyan Li
You Li
Qian Zhao
Zhiyun Wei
Yang Wang
Baojie Li
Guoyin Feng
Lin He
Yongyong Shi
Shanghai Changning Mental Health Center · CNShanghai Jiao Tong University · CNChinese Academy of Sciences · CNShanghai Mental Health Center · CNShanghai Institutes for Biological Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMyelin transcription factor 1-like (MYT1L) is a member of the myelin transcription factor 1 (MYT1) gene family, and the neural specific, zinc-finger-containing, DNA-binding protein that it encodes plays a role in the development of the nervous system. On the basis of a recent copy number variation (CNV) study showing that this gene is disrupted in mental disorder patients, we investigated whether MYT1L also plays a role in MDD.

methodsIn this study, 8 SNPs were analyzed in 1139 MDD patients and 1140 controls of Chinese Han origin.

resultsStatistically significant differences were noted between cases and controls for rs3748989 (allele: permutated p = 0.0079, corrected p = 0.0048, genotype: corrected p = 0.0204). A haplotype of rs1617213 and rs6759709 G-C was also significant (permutated p = 0.00007).

conclusionOur results indicate that MYT1L may be a potential risk gene for MDD in the Chinese Han population.

Indexed as

EthnicityPolymorphism, Single NucleotideCase-Control StudiesChinaDNA-Binding ProteinsGene DosageGenetic Predisposition to DiseaseHumansMajor Depressive DisorderTranscription FactorsDNA-Binding ProteinsMYT1 protein, humanTranscription Factors

Identifiers

PMID21048971
PMCPMC2965102
OpenAlexW2069513236

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.