ArticlePloS one2010
MicroRNAs are mediators of androgen action in prostate and muscle.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 62 citations in OpenAlex.
- Orchestration of miRNA Patterns by Testosterone and Dietary Tomato Carotenoids during Early Prostate Carcinogenesis in TRAMP Mice.The Journal of nutrition · 2023Article
- Androgens alter the heterogeneity of small extracellular vesicles and the small RNA cargo in prostate cancer.Journal of extracellular vesicles · 2021Article
- Coordinated AR and microRNA regulation in prostate cancer.Asian journal of urology · 2020Review
- Growth Hormone(s), Testosterone, Insulin-Like Growth Factors, and Cortisol: Roles and Integration for Cellular Development and Growth With Exercise.Frontiers in endocrinology · 2020Review
- Regulation of TFPIα expression by miR-27a/b-3p in human endothelial cells under normal conditions and in response to androgens.Scientific reports · 2017Article
- Micro-RNA-204 Participates in TMPRSS2/ERG Regulation and Androgen Receptor Reprogramming in Prostate Cancer.Hormones & cancer · 2017Article
- microRNAs and the adolescent brain: Filling the knowledge gap.Neuroscience and biobehavioral reviews · 2016Review
- Development of a novel cell based androgen screening model.The Journal of steroid biochemistry and molecular biology · 2016Article
- Epigenetic and miRNAs Dysregulation in Prostate Cancer: The role of Nutraceuticals.Anti-cancer agents in medicinal chemistry · 2016Review
- The Androgen Receptor Antagonizes Wnt/β-Catenin Signaling in Epidermal Stem Cells.The Journal of investigative dermatology · 2015Article
- Roles for miRNAs in endocrine resistance in breast cancer.Endocrine-related cancer · 2015Review
- Article
- Down-regulation of Dicer and Ago2 is associated with cell proliferation and apoptosis in prostate cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- A dosage-dependent pleiotropic role of Dicer in prostate cancer growth and metastasis.Oncogene · 2014Article
- Uncovering the roles of miRNAs and their relationship with androgen receptor in prostate cancer.IUBMB life · 2014Review
- Signaling involved in hair follicle morphogenesis and development.International journal of molecular sciences · 2014Review
- Androgen receptor splice variant AR3 promotes prostate cancer via modulating expression of autocrine/paracrine factors.The Journal of biological chemistry · 2014Article
- Article
- The role of microRNAs in prostate cancer progression.Translational andrology and urology · 2013Review
- Sheep models of polycystic ovary syndrome phenotype.Molecular and cellular endocrinology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Androgen receptor (AR) function is critical for the development of male reproductive organs, muscle, bone and other tissues. Functionally impaired AR results in androgen insensitivity syndrome (AIS). The interaction between AR and microRNA (miR) signaling pathways was examined to understand the role of miRs in AR function. Reduction of androgen levels in Sprague-Dawley rats by castration inhibited the expression of a large set of miRs in prostate and muscle, which was reversed by treatment of castrated rats with 3 mg/day dihydrotestosterone (DHT) or selective androgen receptor modulators. Knockout of the miR processing enzyme, DICER, in LNCaP prostate cancer cells or tissue specifically in mice inhibited AR function leading to AIS. Since the only function of miRs is to bind to 3' UTR and inhibit translation of target genes, androgens might induce miRs to inhibit repressors of AR function. In concordance, knock-down of DICER in LNCaP cells and in tissues in mice induced the expression of corepressors, NCoR and SMRT. These studies demonstrate a feedback loop between miRs, corepressors and AR and the imperative role of miRs in AR function in non-cancerous androgen-responsive tissues.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.