ArticleFrontiers in aging neuroscience2010
Region-specific genetic alterations in the aging hippocampus: implications for cognitive aging.
Article in Frontiers in aging neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Theta Cordance Decline in Frontal and Temporal Cortices: Longitudinal Evidence of Regional Cortical Aging.Journal of clinical medicine · 2025Article
- Microglial DBP Signaling Mediates Behavioral Abnormality Induced by Chronic Periodontitis in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Hippocampal dentate gyrus integrity revealed with ultrahigh resolution diffusion imaging predicts memory performance in older adults.Hippocampus · 2022Article
- Role of Neural Stem Cells and Vitamin D Receptor (VDR)-Mediated Cellular Signaling in the Mitigation of Neurological Diseases.Molecular neurobiology · 2022Review
- Comparison of the Effects of Cuprizone on Demyelination in the Corpus Callosum and Hippocampal Progenitors in Young Adult and Aged Mice.Neurochemical research · 2022Article
- Rapid Aging in the Perforant Path Projections to the Rodent Dentate Gyrus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Hippocampal Subregion Transcriptomic Profiles Reflect Strategy Selection during Cognitive Aging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- GenusIranian journal of basic medical sciences · 2020Review
- Cognitive Reserve in Model Systems for Mechanistic Discovery: The Importance of Longitudinal Studies.Frontiers in aging neuroscience · 2020Review
- Senescent neurophysiology: CaNeurobiology of learning and memory · 2019Review
- Transcriptomic changes in the prefrontal cortex of rats as a function of age and cognitive engagement.Neurobiology of learning and memory · 2019Article
- A subunit of V-ATPases, ATP6V1B2, underlies the pathology of intellectual disability.EBioMedicine · 2019Article
- Vitamin D Improves Neurogenesis and Cognition in a Mouse Model of Alzheimer's Disease.Molecular neurobiology · 2018Article
- DNA Methyltransferases, DNA Methylation, and Age-Associated Cognitive Function.International journal of molecular sciences · 2018Review
- Environmental enrichment improves hippocampal function in aged rats by enhancing learning and memory, LTP, and mGluR5-Homer1c activity.Neurobiology of aging · 2018Article
- Strength and Aerobic Exercises Improve Spatial Memory in Aging Rats Through Stimulating Distinct Neuroplasticity Mechanisms.Molecular neurobiology · 2017Article
- Neuroinflammatory challenges compromise neuronal function in the aging brain: Postoperative cognitive delirium and Alzheimer's disease.Behavioural brain research · 2017Review
- Hippocampal Transcriptomic Profiles: Subfield Vulnerability to Age and Cognitive Impairment.Frontiers in aging neuroscience · 2017Article
- Human Induced Pluripotent Stem Cells and the Modelling of Alzheimer's Disease: The Human Brain Outside the Dish.The open neurology journal · 2017Review
- Transcription Profile of Aging and Cognition-Related Genes in the Medial Prefrontal Cortex.Frontiers in aging neuroscience · 2016Article
Corrections and comments
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Abstract
Aging is associated with cognitive decline in both humans and animals and of all brain regions, the hippocampus appears to be particularly vulnerable to senescence. Age-related spatial learning deficits result from alterations in hippocampal connectivity and plasticity. These changes are differentially expressed in each of the hippocampal fields known as cornu ammonis 1 (CA1), cornu ammonis 3 (CA3), and the dentate gyrus. Each sub-region displays varying degrees of susceptibility to aging. For example, the CA1 region is particularly susceptible in Alzheimer's disease while the CA3 region shows vulnerability to stress and glucocorticoids. Further, in animals, aging is the main factor associated with the decline in adult neurogenesis in the dentate gyrus. This review discusses the relationship between region-specific hippocampal connectivity, morphology, and gene expression alterations and the cognitive deficits associated with senescence. In particular, data are reviewed that illustrate how the molecular changes observed in the CA1, CA3, and dentate regions are associated with age-related learning deficits. This topic is of importance because increased understanding of how gene expression patterns reflect individual differences in cognitive performance is critical to the process of identifying new and clinically useful biomarkers for cognitive aging.
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Registered trials
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