ArticleProteomics. Clinical applications2009
Toward the Proteome of the Human Peripheral Blood Eosinophil.
Article in Proteomics. Clinical applications, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Integrative Omics of Eosinophils in Asthma and COPD: Deciphering Molecular Signatures for Targeted Therapy.Molecular diagnosis & therapy · 2026Review
- Eosinophils, Basophils, and Neutrophils in Bullous Pemphigoid.Biomolecules · 2023Review
- Galectin-10 as a Potential Biomarker for Eosinophilic Diseases.Biomolecules · 2022Review
- Eosinophil ETosis-Mediated Release of Galectin-10 in Eosinophilic Granulomatosis With Polyangiitis.Arthritis & rheumatology (Hoboken, N.J.) · 2021Article
- Galectin-10, the protein that forms Charcot-Leyden crystals, is not stored in granules but resides in the peripheral cytoplasm of human eosinophils.Journal of leukocyte biology · 2020Article
- The Charcot-Leyden crystal protein revisited-A lysopalmitoylphospholipase and more.Journal of leukocyte biology · 2020Review
- Proinflammatory Effects of Respiratory Syncytial Virus-Induced Epithelial HMGB1 on Human Innate Immune Cell Activation.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Myeloid-derived growth factor is a resident endoplasmic reticulum protein.The Journal of biological chemistry · 2018Article
- Postsynaptic Proteome of Non-Demented Individuals with Alzheimer's Disease Neuropathology.Journal of Alzheimer's disease : JAD · 2018Article
- Proteins Differentially Expressed in the Pancreas of Hepatic Alcohol Dehydrogenase-Deficient Deer Mice Fed Ethanol For 3 Months.Pancreas · 2017Article
- Proteomics of Eosinophil Activation.Frontiers in medicine · 2017Review
- Recent advances in understanding eosinophil biology.F1000Research · 2017Review
- Cytokine-Induced Glucocorticoid Resistance from Eosinophil Activation: Protein Phosphatase 5 Modulation of Glucocorticoid Receptor Phosphorylation and Signaling.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- The Peripheral Blood Eosinophil Proteome.Journal of proteome research · 2016Article
- Eosinophil resistance to glucocorticoid-induced apoptosis is mediated by the transcription factor NFIL3.Apoptosis : an international journal on programmed cell death · 2016Article
- Fear potentiated startle increases phospholipase D (PLD) expression/activity and PLD-linked metabotropic glutamate receptor mediated post-tetanic potentiation in rat amygdala.Neurobiology of learning and memory · 2016Article
- XPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A.Clinical cancer research : an official journal of the American Association for Cancer Research · 2015Article
- IL-5 induces suspended eosinophils to undergo unique global reorganization associated with priming.American journal of respiratory cell and molecular biology · 2014Article
- The cancer drug tamoxifen: a potential therapeutic treatment for spinal cord injury.Journal of neurotrauma · 2014Article
- Arsenal of elevated defense proteins fails to protect tomato against Verticillium dahliae.Planta · 2012Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Eosinophils are granular leukocytes that have significant roles in many inflammatory and immunoregulatory responses, especially asthma and allergic diseases. We have undertaken a fairly comprehensive proteomic analysis of purified peripheral blood eosinophils from normal human donors primarily employing 2-dimensional gel electrophoresis with protein spot identification by matrix-assisted laser desorption/ionization mass spectrometry. Protein subfractionation methods employed included isoelectric focusing (Zoom(®) Fractionator) and subcellular fractionation using differential protein solubilization. We have identified 3,141 proteins which had Mascot expectation scores of 10(-3) or less. Of these 426 were unique and non-redundant of which 231 were novel proteins not previously reported to occur in eosinophils. Ingenuity Pathway Analysis showed that some 70% of the non-redundant proteins could be subdivided into categories that are clearly related to currently known eosinophil biological activities. Cytoskeletal and associated proteins predominated among the proteins identified. Extensive protein posttranslational modifications were evident, many of which have not been previously reported that reflected the dynamic character of the eosinophil. This dataset of eosinophilic proteins will prove valuable in comparative studies of disease versus normal states and for studies of gender differences and polymorphic variation among individuals.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.