ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
State-dependent firing determines intrinsic dendritic Ca2+ signaling in thalamocortical neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- An Update on Stiripentol Mechanisms of Action: A Narrative Review.Advances in therapy · 2024Review
- Article
- Experimentally-constrained biophysical models of tonic and burst firing modes in thalamocortical neurons.PLoS computational biology · 2019Article
- Dual function of thalamic low-vigilance state oscillations: rhythm-regulation and plasticity.Nature reviews. Neuroscience · 2018Review
- Differential alterations of intracellular [CaTranslational brain rhythmicity · 2017Article
- Variable Action Potential Backpropagation during Tonic Firing and Low-Threshold Spike Bursts in Thalamocortical But Not Thalamic Reticular Nucleus Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Sub-synaptic localization of CaBrain structure & function · 2017Article
- Heantos-4, a natural plant extract used in the treatment of drug addiction, modulates T-type calcium channels and thalamocortical burst-firing.Molecular brain · 2016Article
- Passive Synaptic Normalization and Input Synchrony-Dependent Amplification of Cortical Feedback in Thalamocortical Neuron Dendrites.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Characterization of Rebound Depolarization in Neurons of the Rat Medial Geniculate Body In Vitro.Neuroscience bulletin · 2016Article
- The Global Spike: Conserved Dendritic Properties Enable Unique Ca2+ Spike Generation in Low-Threshold Spiking Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Active Dendrites and Differential Distribution of Calcium Channels Enable Functional Compartmentalization of Golgi Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Graded boosting of synaptic signals by low-threshold voltage-activated calcium conductance.Journal of neurophysiology · 2015Article
- Sleep slow wave-related homo and heterosynaptic LTD of intrathalamic GABAAergic synapses: involvement of T-type Ca2+ channels and metabotropic glutamate receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The Thalamus as a Low Pass Filter: Filtering at the Cellular Level does Not Equate with Filtering at the Network Level.Frontiers in neural circuits · 2015Article
- L-type calcium channel-dependent inhibitory plasticity in the thalamus.Journal of neurophysiology · 2014Review
- NMDA spike/plateau potentials in dendrites of thalamocortical neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Cav3 T-type channels: regulators for gating, membrane expression, and cation selectivity.Pflugers Archiv : European journal of physiology · 2014Review
- The many faces of T-type calcium channels.Pflugers Archiv : European journal of physiology · 2014Review
- How voltage-gated calcium channels gate forms of homeostatic synaptic plasticity.Frontiers in cellular neuroscience · 2014Review
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4 authors.
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Abstract
Activity-dependent dendritic Ca(2+) signals play a critical role in multiple forms of nonlinear cellular output and plasticity. In thalamocortical neurons, despite the well established spatial separation of sensory and cortical inputs onto proximal and distal dendrites, respectively, little is known about the spatiotemporal dynamics of intrinsic dendritic Ca(2+) signaling during the different state-dependent firing patterns that are characteristic of these neurons. Here we demonstrate that T-type Ca(2+) channels are expressed throughout the entire dendritic tree of rat thalamocortical neurons and that they mediate regenerative propagation of low threshold spikes, typical of, but not exclusive to, sleep states, resulting in global dendritic Ca(2+) influx. In contrast, actively backpropagating action potentials, typical of wakefulness, result in smaller Ca(2+) influxes that can temporally summate to produce dendritic Ca(2+) accumulations that are linearly related to firing frequency but spatially confined to proximal dendritic regions. Furthermore, dendritic Ca(2+) transients evoked by both action potentials and low-threshold spikes are shaped by Ca(2+) uptake by sarcoplasmic/endoplasmic reticulum Ca(2+) ATPases but do not rely on Ca(2+)-induced Ca(2+) release. Our data demonstrate that thalamocortical neurons are endowed with intrinsic dendritic Ca(2+) signaling properties that are spatially and temporally modified in a behavioral state-dependent manner and suggest that backpropagating action potentials faithfully inform proximal sensory but not distal corticothalamic synapses of neuronal output, whereas corticothalamic synapses only "detect" Ca(2+) signals associated with low-threshold spikes.
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