ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Peptide-induced modulation of synaptic transmission and escape response in Drosophila requires two G-protein-coupled receptors.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- PARK(ing) time-How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease.FEBS letters · 2026Article
- Article
- Insect neuropeptides as agents for pest control: potential and challenges.Biological research · 2025Review
- FMRFamide-like peptides (FaLPs) - an overview of diverse physiological roles in insects and other arthropods.International journal of biological sciences · 2025Review
- Article
- Dietary cysteine drives body fat loss via FMRFamide signaling in Drosophila and mouse.Cell research · 2023Article
- Regulation of excitation-contraction coupling at the Drosophila neuromuscular junction.The Journal of physiology · 2022Article
- Impaired Pre-Motor Circuit Activity and Movement in a Drosophila Model of KCNMA1-Linked Dyskinesia.Movement disorders : official journal of the Movement Disorder Society · 2021Article
- Temporally and spatially partitioned neuropeptide release from individual clock neurons.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- FMRFa receptor stimulated Ca2+ signals alter the activity of flight modulating central dopaminergic neurons in Drosophila melanogaster.PLoS genetics · 2018Article
- Neurogenomic Signatures of Successes and Failures in Life-History Transitions in a Key Insect Pollinator.Genome biology and evolution · 2017Article
- Gene Regulatory Mechanisms Underlying the Spatial and Temporal Regulation of Target-Dependent Gene Expression in Drosophila Neurons.PLoS genetics · 2015Article
- FMRFamide signaling promotes stress-induced sleep in Drosophila.Brain, behavior, and immunity · 2015Article
- Related neuropeptides use different balances of unitary mechanisms to modulate the cardiac neuromuscular system in the American lobster, Homarus americanus.Journal of neurophysiology · 2015Article
- Distinct Regulation of Transmitter Release at the Drosophila NMJ by Different Isoforms of nemy.PloS one · 2015Article
- Article
- A genetic RNAi screen for IP₃/Ca²⁺ coupled GPCRs in Drosophila identifies the PdfR as a regulator of insect flight.PLoS genetics · 2013Article
- Neuropeptide modulation of microcircuits.Current opinion in neurobiology · 2012Review
- Select Neuropeptides and their G-Protein Coupled Receptors in Caenorhabditis Elegans and Drosophila Melanogaster.Frontiers in endocrinology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Neuropeptides are found in both mammals and invertebrates and can modulate neural function through activation of G-protein-coupled receptors (GPCRS). The precise mechanisms by which many of these GPCRs modulate specific signaling cascades to regulate neural function are not well defined. We used Drosophila melanogaster as a model to examine both the cellular and behavioral effects of DPKQDFMRFamide, the most abundant peptide encoded by the dFMRF gene. We show that DPKQDFMRFamide enhanced synaptic transmission through activation of two G-protein-coupled receptors, Fmrf Receptor (FR) and Dromyosupressin Receptor-2 (DmsR-2). The peptide increased both the presynaptic Ca(2+) response and the quantal content of released transmitter. Peptide-induced modulation of synaptic function could be abrogated by depleting intracellular Ca(2+) stores or by interfering with Ca(2+) release from the endoplasmic reticulum through disruption of either the ryanodine receptor or the inositol 1,4,5-trisphosphate receptor. The peptide also altered behavior. Exogenous DPKQDFMRFamide enhanced fictive locomotion; this required both the FR and DmsR-2. Likewise, both receptors were required for an escape response to intense light exposure. Thus, coincident detection of a peptide by two GPCRs modulates synaptic function through effects of Ca(2+)-induced Ca(2+) release, and we hypothesize that these mechanisms are involved in behavioral responses to environmental stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.