ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Capacitance measurements of regulated exocytosis in mouse taste cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed, 39 citations in OpenAlex.
- Receptors and signaling for sour and salty: the ionic taste qualities.Chemical senses · 2025Review
- Expression profile of the zinc transporter ZnT3 in taste cells of rat circumvallate papillae and its role in zinc release, a potential mechanism for taste stimulation.European journal of histochemistry : EJH · 2022Article
- Recent Progress in the Study of Taste Characteristics and the Nutrition and Health Properties of Organic Acids in Foods.Foods (Basel, Switzerland) · 2022Review
- The Role of ATP and Purinergic Receptors in Taste Signaling.Handbook of experimental pharmacology · 2022Review
- Functional expression of TMEM16A in taste bud cells.The Journal of physiology · 2021Article
- Taste transduction and channel synapses in taste buds.Pflugers Archiv : European journal of physiology · 2021Review
- GAD65Cre Drives Reporter Expression in Multiple Taste Cell Types.Chemical senses · 2021Article
- Recent advances in taste transduction and signaling.F1000Research · 2019Review
- ATP Release Channels.International journal of molecular sciences · 2018Review
- Type III Cells in Anterior Taste Fields Are More Immunohistochemically Diverse Than Those of Posterior Taste Fields in Mice.Chemical senses · 2017Article
- Taste buds: cells, signals and synapses.Nature reviews. Neuroscience · 2017Review
- Action potentials and ion conductances in wild-type and CALHM1-knockout type II taste cells.Journal of neurophysiology · 2017Article
- Glutamate: Tastant and Neuromodulator in Taste Buds.Advances in nutrition (Bethesda, Md.) · 2016Review
- Mice Lacking Pannexin 1 Release ATP and Respond Normally to All Taste Qualities.Chemical senses · 2015Article
- Glucagon-like peptide-1 is specifically involved in sweet taste transmission.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Postsynaptic P2X3-containing receptors in gustatory nerve fibres mediate responses to all taste qualities in mice.The Journal of physiology · 2015Article
- Synaptic communication and signal processing among sensory cells in taste buds.The Journal of physiology · 2014Article
- A taste for ATP: neurotransmission in taste buds.Frontiers in cellular neuroscience · 2013Review
- How do taste cells lacking synapses mediate neurotransmission? CALHM1, a voltage-gated ATP channel.BioEssays : news and reviews in molecular, cellular and developmental biology · 2013Review
- High-resolution membrane capacitance measurements for the study of exocytosis and endocytosis.Nature protocols · 2013Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Exocytosis, consisting of the merger of vesicle and plasma membrane, is a common mechanism used by different types of nucleated cells to release their vesicular contents. Taste cells possess vesicles containing various neurotransmitters to communicate with adjacent taste cells and afferent nerve fibers. However, whether these vesicles engage in exocytosis on a stimulus is not known. Since vesicle membrane merger with the plasma membrane is reflected in plasma membrane area fluctuations, we measured membrane capacitance (C(m)), a parameter linearly related to membrane surface area. To investigate whether taste cells undergo regulated exocytosis, we used the compensated tight-seal whole-cell recording technique to monitor depolarization-induced changes in C(m) in the different types of taste cells. To identify taste cell types, mice expressing green fluorescent protein from the TRPM5 promoter or from the GAD67 promoter were used to discriminate type II and type III taste cells, respectively. Moreover, the cell types were also identified by monitoring their voltage-current properties. The results demonstrate that only type III taste cells show significant depolarization-induced increases in C(m), which were correlated to the voltage-activated calcium currents. The results suggest that type III, but neither type II nor type I cells exhibit depolarization-induced regulated exocytosis to release transmitter and activate gustatory afferent nerve fibers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.