ReviewAmerican journal of physiology. Regulatory, integrative and comparative physiology2011
Multiple hypothalamic circuits sense and regulate glucose levels.
Review in American journal of physiology. Regulatory, integrative and comparative physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 105 citations in OpenAlex.
- Aging Effects on Metabolic Sensor and Glycogen Metabolism in Old Male versus Female Rat Primary Hypothalamic Astrocyte Cultures.Neuroglia (Basel, Switzerland) · 2025Article
- Orexin population activity precisely reflects net body movement across behavioral and metabolic states.eLife · 2025Article
- Exposure to predator threat engages sympathetic nervous system outflow to skeletal muscle.Autonomic neuroscience : basic & clinical · 2025Article
- The role and interaction of hypothalamic-related neurotransmitters in migraine.The journal of headache and pain · 2025Review
- Orexin neurons mediate temptation-resistant voluntary exercise.Nature neuroscience · 2024Article
- Coordinated human sleeping brainwaves map peripheral body glucose homeostasis.Cell reports. Medicine · 2023Article
- The hypothalamus as a key regulator of glucose homeostasis: emerging roles of the brain renin-angiotensin system.American journal of physiology. Cell physiology · 2023Review
- Hydrogen Sulfide Attenuates High-Fat Diet-Induced Obesity: Involvement of mTOR/IKK/NF-κB Signaling Pathway.Molecular neurobiology · 2022Article
- Contrasting dose-dependent effects of acute intravenous methamphetamine on lateral hypothalamic extracellular glucose dynamics in male and female rats.Journal of neurophysiology · 2022Article
- Stimulation of the hepatoportal nerve plexus with focused ultrasound restores glucose homoeostasis in diabetic mice, rats and swine.Nature biomedical engineering · 2022Article
- REV-ERB nuclear receptors in the suprachiasmatic nucleus control circadian period and restrict diet-induced obesity.Science advances · 2021Article
- Review
- Orexin/Hypocretin and MCH Neurons: Cognitive and Motor Roles Beyond Arousal.Frontiers in neuroscience · 2021Review
- 17β-estradiol promotes acute refeeding in hungry mice via membrane-initiated ERα signaling.Molecular metabolism · 2020Article
- Changes in neuronal activity across the mouse ventromedial nucleus of the hypothalamus in response to low glucose: Evaluation using an extracellular multi-electrode array approach.Journal of neuroendocrinology · 2020Article
- Noninvasive Neuromodulation of Peripheral Nerve Pathways Using Ultrasound and Its Current Therapeutic Implications.Cold Spring Harbor perspectives in medicine · 2020Review
- Physiological Implications of Orexins/Hypocretins on Energy Metabolism and Adipose Tissue Development.ACS omega · 2020Article
- High-Fat Diets and LXRs Expression in Rat Liver and Hypothalamus.Cellular and molecular neurobiology · 2019Article
- High-fat diet consumption alters energy metabolism in the mouse hypothalamus.International journal of obesity (2005) · 2019Article
- Diabetes Mellitus-Related Fractional Glucose Uptake in Men and Women Imaged WithJournal of the Endocrine Society · 2019Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hypothalamus monitors body energy status in part through specialized glucose sensing neurons that comprise both glucose-excited and glucose-inhibited cells. Here we discuss recent work on the elucidation of neurochemical identities and physiological significance of these hypothalamic cells, including caveats resulting from the currently imprecise functional and molecular definitions of glucose sensing and differences in glucose-sensing responses obtained with different experimental techniques. We discuss the recently observed adaptive glucose-sensing responses of orexin/hypocretin-containing neurons, which allow these cells to sense changes in glucose levels rather than its absolute concentration, as well as the glucose-sensing abilities of melanin-concentrating hormone, neuropeptide Y, and proopiomelanocortin-containing neurons and the recent data on the role of ventromedial hypothalamic steroidogenic factor-1 (SF-1)/glutamate-containing cells in glucose homeostasis. We propose a model where orexin/hypocretin and SF-1/glutamate neurons cooperate in stimulating the sympathetic outflow to the liver and pancreas to increase blood glucose, which in turn provides negative feedback inhibition to these cells. Orexin/hypocretin neurons also stimulate feeding and reward seeking and are activated by hunger and stress, thereby providing a potential link between glucose sensing and goal-oriented behavior. The cell-type-specific neuromodulatory actions of glucose in several neurochemically distinct hypothalamic circuits are thus likely to be involved in coordinating higher brain function and behavior with autonomic adjustments in blood glucose levels.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.