ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2011
Exercise training reverses impaired skeletal muscle metabolism induced by artificial selection for low aerobic capacity.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- miR-19b-3p is associated with a diametric response to resistance exercise in older adults and regulates skeletal muscle anabolism via PTEN inhibition.American journal of physiology. Cell physiology · 2021Trial
- Skeletal muscle Nur77 and NOR1 insulin responsiveness is blunted in obesity and type 2 diabetes but improved after exercise training.Physiological reports · 2019Trial
- Intrinsic exercise capacity is associated with skeletal muscle clock gene and IGF-1 signaling in aged low- and high-running capacity rats.Frontiers in physiology · 2026Article
- Review
- Article
- Parental cardiorespiratory fitness influences early life energetics and metabolic health.Physiological genomics · 2024Article
- Genetically determined exercise capacity affects systemic glucose response to insulin in rats.Physiological genomics · 2021Article
- Low Citrate Synthase Activity Is Associated with Glucose Intolerance and Lipotoxicity.Journal of nutrition and metabolism · 2019Article
- Theoretical and Biological Evaluation of the Link between Low Exercise Capacity and Disease Risk.Cold Spring Harbor perspectives in medicine · 2018Review
- The Orphan Nuclear Receptor 4A1: A Potential New Therapeutic Target for Metabolic Diseases.Journal of diabetes research · 2018Review
- Expression of microRNAs and target proteins in skeletal muscle of rats selectively bred for high and low running capacity.American journal of physiology. Endocrinology and metabolism · 2017Article
- Voluntary Running Attenuates Metabolic Dysfunction in Ovariectomized Low-Fit Rats.Medicine and science in sports and exercise · 2017Article
- Deficiency in the Heat Stress Response Could Underlie Susceptibility to Metabolic Disease.Diabetes · 2016Article
- Article
- Label-free profiling of white adipose tissue of rats exhibiting high or low levels of intrinsic exercise capacity.Proteomics · 2015Article
- Role of intrinsic aerobic capacity and ventilator-induced diaphragm dysfunction.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Implications of exercise training and distribution of protein intake on molecular processes regulating skeletal muscle plasticity.Calcified tissue international · 2015Review
- Conditional independence mapping of DIGE data reveals PDIA3 protein species as key nodes associated with muscle aerobic capacity.Journal of proteomics · 2014Article
- Differential skeletal muscle proteome of high- and low-active mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Leanness and heightened nonresting energy expenditure: role of skeletal muscle activity thermogenesis.American journal of physiology. Endocrinology and metabolism · 2014Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
We have used a novel model of genetically imparted endurance exercise capacity and metabolic health to study the genetic and environmental contributions to skeletal muscle glucose and lipid metabolism. We hypothesized that metabolic abnormalities associated with low intrinsic running capacity would be ameliorated by exercise training. Selective breeding for 22 generations resulted in rat models with a fivefold difference in intrinsic aerobic capacity. Low (LCR)- and high (HCR)-capacity runners remained sedentary (SED) or underwent 6 wk of exercise training (EXT). Insulin-stimulated glucose transport, insulin signal transduction, and rates of palmitate oxidation were lower in LCR SED vs. HCR SED (P < 0.05). Decreases in glucose and lipid metabolism were associated with decreased β₂-adrenergic receptor (β₂-AR), and reduced expression of Nur77 target proteins that are critical regulators of muscle glucose and lipid metabolism [uncoupling protein-3 (UCP3), fatty acid transporter (FAT)/CD36; P < 0.01 and P < 0.05, respectively]. EXT reversed the impairments to glucose and lipid metabolism observed in the skeletal muscle of LCR, while increasing the expression of β₂-AR, Nur77, GLUT4, UCP3, and FAT/CD36 (P < 0.05) in this tissue. However, no metabolic improvements were observed following exercise training in HCR. Our results demonstrate that metabolic impairments resulting from genetic factors (low intrinsic aerobic capacity) can be overcome by an environmental intervention (exercise training). Furthermore, we identify Nur77 as a potential mechanism for improved skeletal muscle metabolism in response to EXT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.